Target Name: LMAN1
NCBI ID: G3998
Review Report on LMAN1 Target / Biomarker Content of Review Report on LMAN1 Target / Biomarker
LMAN1
Other Name(s): Lectin mannose-binding 1 | FMFD1 | ERGIC-53 | intracellular mannose-specific lectin MR60 | Protein ERGIC-53 | endoplasmic reticulum-golgi intermediate compartment protein 53 | LMAN1_HUMAN | lectin, mannose binding 1 | Intracellular mannose-specific lectin MR60 | Lectin, mannose binding 1 | ERGIC53 | Gp58 | Endoplasmic reticulum-golgi intermediate compartment protein 53 | Intracellular mannose specific lectin | F5F8D | MR60 | ER-Golgi intermediate compartment 53 kDa protein | MCFD1 | gp58

LMAN1: A Potential Drug Target and Biomarker for Mannerisms-Induced Atherosclerosis

Atherosclerosis is a leading cause of cardiovascular disease, responsible for the majority of deaths worldwide. It is a complex condition that involves the buildup of plaque in the arterial walls, leading to narrowing or blockages. The underlying mechanisms of atherosclerosis are not fully understood, but it is thought to involve an imbalance of pro-inflammatory and anti-inflammatory processes.

LMAN1, a protein that is expressed in the endothelium (the lining of the blood vessels), has been identified as a potential drug target and biomarker for atherosclerosis. In this article, we will discuss the role of LMAN1 in the development and progression of atherosclerosis, as well as its potential as a drug target.

Expression and Localization of LMAN1 in Atherosclerosis

Atherosclerosis is a condition that involves the buildup of plaque in the arterial walls, leading to narrowing or blockages. The endothelium, the lining of the blood vessels, plays a crucial role in the regulation of blood vessel function and is a key target for the development of atherosclerosis.

LMAN1 is a protein that is expressed in the endothelium and is involved in the regulation of blood vessel diameter and permeability. It is a member of thelectin family, which includes proteins that are involved in cell-cell and cell-extracellular matrix interactions. LMAN1 is expressed in the endothelium and is localized to the intercellular junctions of endothelial cells.

During the development of atherosclerosis, LMAN1 is involved in the regulation of the inflammatory response and immune cell recruitment. It has been shown to play a role in the regulation ofT-cell migration and the production of pro-inflammatory cytokines.

In addition, LMAN1 is also involved in the regulation of cell signaling pathways that are important for the development of atherosclerosis. For example, LMAN1 has been shown to be involved in the regulation of the Notch signaling pathway, a pathway that is involved in the development of plaque in the arterial walls.

Potential Drug Targets for LMAN1

The potential use of LMAN1 as a drug target is based on its involvement in the regulation of the inflammatory response and immune cell recruitment, as well as its role in the regulation of cell signaling pathways that are important for the development of atherosclerosis.

One potential drug that may target LMAN1 is a small molecule inhibitor of Notch signaling, such as SL-401. Notch signaling is a pathway that is involved in the development of plaque in the arterial walls and has been implicated in the development of atherosclerosis. By inhibiting Notch signaling, SL-401 has been shown to be effective in reducing the formation of plaque in the arterial walls.

Another potential drug that may target LMAN1 is a protein kinase C (PKC) inhibitor. PKC is a protein that is involved in the regulation of many cellular processes, including the regulation of cell signaling pathways. By inhibiting PKC, LMAN1 may be able to reduce the inflammation and immune cell recruitment that are involved in the development of atherosclerosis.

Biomarker Potential for LMAN1

As mentioned earlier, LMAN1 is a protein that is expressed in the endothelium and is involved in the regulation of blood vessel diameter and permeability. It is possible to use LMAN1 as a biomarker for the development and progression of atherosclerosis.

One potential method of using LMAN1 as a biomarker is to measure the levels of LMAN1 in the endothelium as a function of the severity of atherosclerosis. This could be done by measuring the levels of LMAN1 in endothelial cells that have been isolated from patients with

Protein Name: Lectin, Mannose Binding 1

Functions: Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins

The "LMAN1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LMAN1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

LMAN1L | LMAN2 | LMAN2L | LMBR1 | LMBR1L | LMBRD1 | LMBRD2 | LMCD1 | LMCD1-AS1 | LMF1 | LMF2 | LMLN | LMNA | LMNB1 | LMNB2 | LMNTD1 | LMNTD2 | LMNTD2-AS1 | LMO1 | LMO2 | LMO3 | LMO4 | LMO7 | LMO7-AS1 | LMO7DN | LMOD1 | LMOD2 | LMOD3 | LMTK2 | LMTK3 | LMX1A | LMX1B | LMX1B-DT | LNC-LBCS | LNCAROD | LNCARSR | LNCATV | LNCNEF | LNCOC1 | LNCOG | LNCPRESS1 | LNCRI | LNCRNA-ATB | LNCRNA-IUR | LNCTAM34A | LNP1 | LNPEP | LNPK | LNX1 | LNX1-AS1 | LNX2 | LOC100127946 | LOC100127955 | LOC100128002 | LOC100128028 | LOC100128050 | LOC100128059 | LOC100128079 | LOC100128093 | LOC100128164 | LOC100128242 | LOC100128288 | LOC100128317 | LOC100128361 | LOC100128398 | LOC100128494 | LOC100128593 | LOC100128770 | LOC100128966 | LOC100128988 | LOC100129034 | LOC100129098 | LOC100129148 | LOC100129175 | LOC100129203 | LOC100129215 | LOC100129316 | LOC100129381 | LOC100129434 | LOC100129455 | LOC100129534 | LOC100129603 | LOC100129697 | LOC100130000 | LOC100130207 | LOC100130285 | LOC100130298 | LOC100130331 | LOC100130452 | LOC100130463 | LOC100130548 | LOC100130587 | LOC100130691 | LOC100130698 | LOC100130744 | LOC100130748 | LOC100130872 | LOC100130899 | LOC100130938 | LOC100130987