MIR194-2: A Potential Drug Target (G406970)

MIR194-2: A Potential Drug Target

MIR194-2 (hsa-mir-194-2) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, and gastrointestinal tract. It is a member of the heparan sulfate proteoglycan (HSPG) family , which is a type of glycosaminoglycan (GBG) that is involved in cell-cell adhesion, migration, and signaling.

MIR194-2 has been identified as a potential drug target due to its involvement in several diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its role in these diseases has led to a growing interest in developing compounds that can specifically target MIR194-2 and modulate its activity.

One of the key challenges in studying MIR194-2 is its complex structure. MIR194-2 is a monomer with a unique N-terminal region that consists of a heparan sulfate repeat and a protein-coding domain. This region is known as the N- terminal transmembrane domain (N-TMD) and is responsible for MIR194-2's unique biological functions.

The N-TMD is made up of a series of alternating disulfide bonds, which form a ring-shaped structure when viewed from the side. This structure is thought to play a role in MIR194-2's stability and stability in various cellular compartments. In addition , the N-TMD is involved in MIR194-2's ability to interact with other proteins, including cadherins and integrins, which are important cell surface molecules involved in cell-cell adhesion and migration.

MIR194-2 has also been shown to play a role in modulating the activity of various signaling pathways, including the TGF-β pathway. This pathway is involved in cell growth, differentiation, and survival, and is a key regulator of many diseases, including cancer. MIR194-2 has been shown to interact with the protein SMAD2, which is a key regulator of the TGF-β pathway. This interaction may play a role in MIR194-2's regulation of cellular processes, including cell growth, apoptosis, and inflammation.

Another potential mechanism by which MIR194-2 may contribute to disease is its role in modulating the activity of the immune system. MIR194-2 has been shown to interact with the protein PDGF-R2, which is involved in the regulation of cellular processes that are critical for immune responses. This interaction may play a role in MIR194-2's regulation of immune cell function, including the regulation of T cell development and activation.

In conclusion, MIR194-2 is a protein that is involved in a number of important cellular processes in the body. Its unique structure and role in several diseases make it an attractive target for drug development. Further research is needed to fully understand the mechanisms of MIR194-2's biology and its potential as a drug target.

Protein Name: MicroRNA 194-2

The "MIR194-2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MIR194-2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

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