COL18A1: A Multi-Functional Protein MFP as a Potential Drug Target and Biomarker

Target Name: COL18A1

NCBI ID: G80781

COL18A1

COL18A1: A Multi-Functional Protein MFP as a Potential Drug Target and Biomarker

Several diseases are characterized by the overproduction or underproduction of specific proteins. The protein balance in the body is crucial for maintaining cellular health and proper function. Abnormal protein levels can lead to the development of various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. One of the promising strategies to combat these conditions is to target and manipulate the expression of specific proteins. In this article, we will focus on the protein COL18A1, its function, and its potential as a drug target and biomarker.

Biochemical and Functional Characterization of COL18A1

COL18A1, also known as interleukin-18 (IL-18), is a cytokine that plays a crucial role in the regulation of immune and inflammatory responses. It is a member of the IL-18 family, which includes several cytokines, including IL-1, IL-2, IL-3, and IL-4. These cytokines are involved in the recruitment and activation of immune cells, such as T cells and neutrophils, which are critical for fighting off infections and diseases.

COL18A1 is a 14-kDa protein that is expressed in various tissues and cells, including immune cells, tissues, and organs. It is involved in the regulation of cellular processes, including cell adhesion, migration, and survival. COL18A1 has been shown to play a role in the regulation of immune cell function, including the T cell response to antigens.

Expression and Modulation of COL18A1

COL18A1 is highly expressed in various tissues and cells, including immune cells, cancer cells, and cancer-initiating cells. It has been shown to be involved in the regulation of cellular processes, including cell adhesion, migration, and survival. The expression of COL18A1 can be regulated by various factors, including cytokines, chemokines, and transcription factors.

One of the well-known mechanisms of COL18A1 regulation is its role in the regulation of T cell development and function. T cells are a crucial immune cell that play a central role in fighting off infections and diseases. The regulation of T cell development and function is critical for maintaining cellular health and proper function. COL18A1 has been shown to play a role in the regulation of T cell development and function, including the regulation of T cell receptor (TCR) function.

Another mechanism of COL18A1 regulation is its role in the regulation of cancer cell growth and survival. Cancer cells have the ability to evade the immune system's surveillance and attacks. The regulation of cancer cell growth and survival is critical for the development and progression of cancer. COL18A1 has been shown to play a role in the regulation of cancer cell growth and survival, including the regulation of cell cycle progression and apoptosis.

Drug Target and Biomarker Potential

The overproduction or underproduction of specific proteins, including COL18A1, has been implicated in the development and progression of various diseases. The regulation of cellular processes by COL18A1 is a potential drug target. Several studies have shown that inhibition of COL18A1 can lead to the downregulation of various cellular processes, including cell adhesion, migration, and survival.

In addition, the regulation of cellular processes by COL18A1 has also been implicated in the development of various diseases, including cancer. The regulation of cell cycle progression and apoptosis by COL18A1 has been shown to play a role in the development and progression of cancer. Therefore, targeting COL18A1 with small molecules or antibodies may be an effective strategy for the treatment of cancer.

COL18A1 has also been shown to be a potential biomarker for several diseases, including cancer. The regulation of cellular processes by COL18A1 has

Protein Name: Collagen Type XVIII Alpha 1 Chain

Functions: Probably plays a major role in determining the retinal structure as well as in the closure of the neural tube

The "COL18A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about COL18A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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