Unlocking the Potential of COL11A1 (DFNA37) as a Drug Target and Biomarker

Target Name: COL11A1

NCBI ID: G1301

COL11A1

Unlocking the Potential of COL11A1 (DFNA37) as a Drug Target and Biomarker

Introduction

COL11A1 (DFNA37) is a protein that is expressed in various tissues of the human body, including the lungs, heart, kidneys, and brain. Its function is not well understood, but it is known to play a role in cell signaling, specifically in the regulation of cell adhesion and migration. In recent years, scientists have discovered that it plays an important role in the onset of many diseases, such as lung cancer, liver cancer, breast cancer, etc. Therefore, studying COL11A1 (DFNA37) as a drug target and biomarker has important clinical value. This article will introduce in detail the structure, function, possibility of being a drug target and application prospects as a biomarker of COL11A1 (DFNA37), providing a certain theoretical basis for related research.

1. Structural characteristics

COL11A1 (DFNA37) is a glycoprotein encoded by the human chromosome 1p36.2 region. It consists of two subunits: the N-terminal 伪-helical domain and the C-terminal 尾-sheet domain. The 伪-helical domain is located at the N-terminus, linearly arranged, and consists of 36 amino acids. The 尾-sheet domain is located at the C-terminus, arranged in a Z-shape, and consists of 19 amino acids. The two subunits are connected through a 尾-sheet structure.

2. Functional analysis

1. Participate in cell signaling

COL11A1 (DFNA37) plays an important role in various cancers, such as lung cancer, liver cancer, breast cancer, etc. Research shows that it is involved in cell signaling, including cell proliferation, differentiation, and apoptosis. Especially in lung cancer, the expression level of COL11A1 (DFNA37) is high and is closely related to the prognosis of lung cancer. Therefore, studying the mechanism of COL11A1 (DFNA37) in lung cancer and revealing its new treatment strategies have important clinical value.

2. Participate in cell adhesion and migration

Studies have shown that COL11A1 (DFNA37) is involved in cell adhesion and migration in a variety of tumors. It can bind to extracellular matrix molecules, thereby enhancing the adhesion and metastasis capabilities of tumor cells. At the same time, the expression level of COL11A1 (DFNA37) in tumor cells is also closely related to the ability of tumor invasion and metastasis. Therefore, studying the mechanism of COL11A1 (DFNA37) in tumor cell adhesion and migration will provide new ideas for finding new treatment strategies.

3. Participate in cell apoptosis

Studies have shown that COL11A1 (DFNA37) is involved in cell apoptosis in a variety of tumors. It can regulate cell apoptosis through a series of signaling pathways, thereby killing tumor cells. At the same time, the expression level of COL11A1 (DFNA37) is also related to tumor apoptosis. Therefore, studying the mechanism of COL11A1 (DFNA37) in tumor cell apoptosis provides new ideas for revealing the regulatory mechanism of tumor cell apoptosis.

3. Possibility as a drug target

Since COL11A1 (DFNA37) plays an important role in various cancers, it is of high value to study its possibility as a drug target. By inhibiting the activity of COL11A1 (DFNA37), the proliferation, differentiation and apoptosis of tumor cells can be inhibited, thereby achieving the purpose of treating tumors. Currently, some drugs targeting COL11A1 (DFNA37) are in the clinical research stage, such as anti-angiogenic drugs, anti-tumor drugs, etc. The study of these drugs provides an important theoretical basis for studying COL11A1 (DFNA37) as a drug target.

4. Application prospects as biomarkers

Studies have shown that COL11A1 (DFNA37) is expressed in a variety of tumors, and the expression level is related to the tumor's

Protein Name: Collagen Type XI Alpha 1 Chain

Functions: May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils

The "COL11A1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about COL11A1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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