THAP4: A Potential Drug Target and Biomarker (G51078)

Target Name: THAP4

NCBI ID: G51078

THAP4

THAP4: A Potential Drug Target and Biomarker

THAP (Tissue Hydrogenpermeable Antipathy Protein) is a protein that is expressed in various tissues and cell types in the human body. It is a member of the superfamily of cytoplasmic proteins, which are involved in various cellular processes such as cytoskeletal organization, cell signaling, and inflammation. One of the unique features of THAP4 is its ability to interact with and modulate the activity of various transcription factors, including NF-kappa-B, p53, and SMN. This property makes THAP4 an attractive candidate for drug targeting and biomarker development.

In recent years, the study of THAP4 has primarily focused on its role in cancer biology. THAP4 has been shown to play a critical role in the regulation of cell proliferation, apoptosis (programmed cell death), and angiogenesis (the formation of new blood vessels). Its involvement in these processes makes THAP4 a potential drug target for cancer therapies.

One of the key mechanisms by which THAP4 promotes cancer growth is its ability to inhibit the inhibition of cell proliferation. THAP4 has been shown to enhance the effects of inhibitors on cell growth, suggesting that it may play a role in the development of resistant cancer cells. This finding has important implications for the development of cancer therapies that are effective in the long term.

Another mechanism by which THAP4 promotes cancer growth is its role in the regulation of apoptosis. THAP4 has been shown to regulate the expression of genes involved in cell apoptosis, which is a critical process for the elimination of damaged or dysfunctional cells. This finding suggests that THAP4 may be a useful biomarker for the assessment of cancer risk and the effectiveness of therapeutic treatments.

In addition to its role in cancer biology, THAP4 has also been shown to be involved in the regulation of cellular signaling pathways. THAP4 has been shown to interact with and modulate the activity of various transcription factors, including NF-kappa-B, p53, and SMN. This suggests that THAP4 may be involved in the regulation of cellular processes that are critical for the maintenance of cellular homeostasis.

Given its involvement in various cellular processes, THAP4 is an attractive candidate for drug targeting and biomarker development. Researchers have been exploring the use of small molecules and other compounds to modulate the activity of THAP4 and its downstream targets. Initial studies have shown that several small molecules have the potential to inhibit the activity of THAP4 and its downstream targets, making them promising candidates for further development as cancer therapies.

In conclusion, THAP4 is a protein that has been shown to play a critical role in various cellular processes, including the regulation of cell proliferation, apoptosis, and cellular signaling pathways. Its involvement in these processes makes THAP4 an attractive candidate for drug targeting and biomarker development. Further research is needed to fully understand the role of THAP4 in cancer biology and its potential as a cancer therapeutic.

Protein Name: THAP Domain Containing 4

Functions: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region

The "THAP4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about THAP4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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