Them5: A Protein Involved in Acyl-CoA Detoxification and Energy Metabolism

Target Name: THEM5

NCBI ID: G284486

THEM5

Them5: A Protein Involved in Acyl-CoA Detoxification and Energy Metabolism

Them5 is a protein that is expressed in various tissues throughout the body, including the liver, heart, kidneys, and lungs. It is a member of the superfamily of ATP-binding proteins, known as the P-type ATPases. These proteins are involved in the regulation of cellular processes that are energy-dependent, including metabolism, growth, and reproduction.

One of the unique features of Them5 is its role in the detoxification of acyl-coenzyme A (acyl-CoA), which is a crucial molecule in the citric acid cycle, also known as the Krebs cycle or TCA cycle. The citric acid cycle is a central metabolic pathway that generates energy in the form of ATP, NADH, and FADH2, which are essential for various cellular processes.

In recent years, the study of acyl-CoA has gained significant attention due to its role in the development and progression of various diseases, including heart disease, diabetes, and cancer. The ability of acyl-CoA to be detoxified by Them5 could be a potential drug target or biomarker, with potential therapeutic applications.

Them5 function and structure

Them5 is a 26-kDa protein that is composed of 216 amino acids. It has a characteristic Rossmann-fold, which is a structural motif that is commonly found in proteins that bind nucleotides, such as ATP and FAD. This motif is responsible for the protein's ability to bind to nucleotides and for the regulation of cellular processes that are energy-dependent.

Them5 plays a crucial role in the detoxification of acyl-CoA. Acyl-CoA is a toxic molecule that can cause damage to various cellular organelles, including the mitochondria and the endoplasmic reticulum. Them5 is able to bind to acyl-CoA and remove it from the molecule, which reduces its toxicity and protects the cell from damage.

Them5 is also involved in the regulation of cellular processes that are energy-dependent. It is a component of the citric acid cycle and is involved in the production of ATP, NADH, and FADH2, which are essential for the production of energy in the cell.

Expression and regulation

Them5 is expressed in various tissues throughout the body, including the liver, heart, kidneys, and lungs. It is primarily expressed in the liver, with lower levels found in the heart, kidneys, and lungs. Them5 is regulated by various factors, including cytokines, growth factors, and hormones.

Them5 can be regulated by the cytokine interferon-gamma (IFN-纬), which is a protein that is produced by the immune system in response to the infection or inflammation. IFN-纬 has been shown to play a role in the regulation of acyl-CoA levels and the detoxification of acyl-CoA by Them5.

IFN-纬 can also be regulated by the transcription factor nuclear factor kappa B (NF-kappa-B), which is a protein that is involved in the regulation of cellular processes that are energy-dependent. NF-kappa-B can activate the expression of Them5 and regulate its levels in the cell.

Them5 has also been shown to be regulated by various hormones, including angiotensin II, which is a hormone that is produced by the adrenal gland in response to the stress hormone. Angiotensin II can activate the expression of Them5 and increase its levels in the cell.

Drug targeting

Them5 is a potential drug target due to its role in the detoxification of acyl-CoA and its involvement in the regulation of cellular processes that are energy-dependent. Various studies have shown that targeting The

Protein Name: Thioesterase Superfamily Member 5

Functions: Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271)

The "THEM5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about THEM5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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