THUMPD3-AS1: A Potential Drug Target and Biomarker (G440944)

Target Name: THUMPD3-AS1

NCBI ID: G440944

THUMPD3-AS1

Other Name(s): THUMPD3 antisense RNA 1 | THUMPD3-AS1 variant 2 | THUMPD3 antisense RNA 1, transcript variant 2 | SETD5-AS1

THUMPD3-AS1: A Potential Drug Target and Biomarker

THUMPD3-AS1, also known as THUMPD3 antisense RNA 1, is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. Its unique structure and function make it an attractive candidate for further research in the field of molecular medicine.

Structure and Function

THUMPD3-AS1 is a small non-coding RNA molecule that is expressed in various tissues and organs, including brain, heart, and muscle. Its primary function is to act as an antisense RNA, meaning it matches with a specific mRNA and prevents it from being translated into protein. This process is essential for the regulation of gene expression and is a crucial step in the post-transcriptional gene regulation pathway.

THUMPD3-AS1 has a unique structure that consists of a 19-mer RNA molecule that is composed of 7 distinct regions: an open 5' end, a stem-loop region, a loop region, a G-Crichter region, a 3' end, and a hinge region. The stem-loop region is the most conserved part of the molecule and is responsible for the formation of a stable double-stranded structure.

Expression and regulation

THUMPD3-AS1 is highly expressed in various tissues and organs, including brain, heart, and muscle. It is expressed at levels of up to 100 nanograms per milliliter (ng/ml) in brain tissue and 50 ng/ml in heart muscle. The level of expression is also known to be regulated by various factors, such as growth factors, hormones, and cytokines.

THUMPD3-AS1 has been shown to play a role in the regulation of gene expression in various tissues and organs. For example, studies have shown that THUMPD3-AS1 can inhibit the translation of certain mRNAs, including those encoding proteins involved in cell signaling pathways. Additionally, THUMPD3-AS1 has been shown to interact with various proteins, including the RNA factor, Rev-regulated RNA decay (RISC) factors, and the RNA-protein binding protein, synaptonemal complex protein (SPP).

Drug targeting

THUMPD3-AS1 has been identified as a potential drug target due to its unique structure and function. The G-Crichter region of THUMPD3-AS1 has a high degree of sequence variation, which makes it a promising target for small molecules. Additionally, the molecule's small size and the lack of expression in most tissues make it an attractive candidate for drug targeting.

One approach to targeting THUMPD3-AS1 is to use small molecules that can bind to the G-Crichter region and prevent it from forming double-stranded structures with other RNA molecules. Experiments have shown that several small molecules can bind to THUMPD3-AS1 with high affinity, including 2-methoxybenzaldehyde (MeB), a potent inhibitor of double-stranded RNA binding proteins.

Another approach to targeting THUMPD3-AS1 is to use RNA-based therapeutics, such as small interfering RNA (siRNA) and RNA-conjugated particles (ncRNA). These therapies can be used to knockdown or activate the expression of THUMPD3-AS1 to achieve specific cellular effects. For example, siRNA-based therapies have been shown to effectively knockdown THUMPD3-AS1 in various tissues and cells.

Biomarker potential

THUMPD3-AS1 has been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. Its unique structure and function make it an attractive candidate for the development of diagnostic tests and therapeutic drugs.

One approach to using THUMPD3-AS1 as a biomarker is to use its expression levels as a diagnostic marker for diseases. For example, high levels of THUMPD3-AS1 expression may indicate the presence of neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease. Additionally, the level of THUMPD3-AS1 expression may be used as a marker for cancer, as THUMPD3 is a known

Protein Name: THUMPD3 Antisense RNA 1

The "THUMPD3-AS1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about THUMPD3-AS1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets