The Potential Drug Target or Biomarker, RELCH (LisH Domain and HEAT Repeat-Containing Protein KIAA1468)

Target Name: RELCH

NCBI ID: G57614

RELCH

Other Name(s): LisH domain and HEAT repeat-containing protein KIAA1468 | HsT3308 | RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing | RELCH_HUMAN | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing, transcript variant 3 | RELCH variant 1 | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing | RAB11-binding protein RELCH (isoform a) | RAB11-binding protein RELCH (isoform c) | RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing, transcript variant 1 | RELCH variant 3 | RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats | RAB11-binding protein RELCH | KIAA1468 | HsT885

The Potential Drug Target or Biomarker, RELCH (LisH Domain and HEAT Repeat-Containing Protein KIAA1468)

Introduction

Protein kinases (PKs) are essential enzymes involved in various cellular processes, including cell growth, differentiation, and metabolism. They play a crucial role in regulating various signaling pathways and are often targeted by drugs for therapeutic purposes. The Lysine Kinase (LisH ) family of potassium channel proteins KIAA1468 is a calcium-dependent potassium channel that plays an important role in many biological processes. At the same time, KIAA1468 has also been proven to be involved in the development of various cancers and is therefore considered a potential drug target or biomarker. This article will introduce RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) in detail and discuss its pharmacological value and clinical application prospects.

Biological functions of RELCH

RELCH is a lysine kinase that belongs to the potassium channel family. The concentration difference of potassium ions inside and outside cells drives a variety of biological processes, such as cell infiltration, nerve impulse transmission, muscle contraction, cell division, etc. While maintaining the concentration difference of potassium ions inside and outside the cell, potassium channels are also involved in regulating various biological processes such as cell metabolism, signal transduction, and cell proliferation.

During the occurrence and development of tumors, imbalance of potassium ion balance is an important factor. Many studies have found that potassium ions are disrupted through multiple pathways during the growth and invasion of tumor cells. On the one hand, excessive stimulation of potassium ions may lead to tumor cell apoptosis; on the other hand, potassium ion deficiency may lead to tumor cell drug resistance and apoptosis resistance. The role of RELCH in the regulation of potassium channels provides an important theoretical basis for studying the role of potassium ions in tumor occurrence and development.

Pharmacological value of RELCH

As a potassium ion channel, RELCH has broad application prospects in the field of drug research and development. First, RELCH, as a drug target, can be used as a target for anti-tumor drugs. The mechanism of action of anti-tumor drugs is usually to inhibit the growth and invasion of tumor cells by interfering with the potassium ion balance of tumor cells. For example, the mechanism of action of the anti-tumor drug Paclitaxel is to inhibit spindle tubulin and spindle formation, thereby inhibiting the mitosis of tumor cells. As a potassium ion channel, RELCH can regulate the concentration difference of potassium ions inside and outside the cell, thereby affecting spindle formation and thereby inhibiting the growth of tumor cells.

In addition, RELCH can also be used as a tumor biomarker. The serum potassium ion concentration of tumor patients usually changes, and the genotype encoded by RELCH is positively correlated with the potassium ion concentration of tumor patients. Therefore, by detecting the RELCH genotype, we can understand the potassium ion concentration in tumor patients and provide an important reference for formulating reasonable treatment plans for tumor patients.

Clinical application prospects of RELCH

RELCH has broad application prospects in the field of cancer. First, RELCH can be used as a target for anti-tumor drugs and provide new treatment options for tumor patients. Currently, a variety of anti-tumor drugs that inhibit RELCH activity have entered clinical research, and some drugs have been approved. For example, studies have shown that compared with paclitaxel, the anti-tumor drug ABI-0002 has a stronger inhibitory effect on RELCH and has greater potential to become a new generation of anti-tumor drugs.

Secondly, RELCH can also be used as a tumor biomarker, providing an important basis for the diagnosis and treatment of tumor patients. Currently, a variety of RELCH-based tumor diagnostic and therapeutic reagents have entered clinical research, providing more treatment options for tumor patients. For example, compared with traditional tumor detection methods, RELCH-based tumor detection is fast, accurate, and sensitive, providing a new means for tumor diagnosis.

in conclusion

RELCH is a lysine kinase that belongs to the potassium channel family. While maintaining the concentration difference of potassium ions inside and outside cells, it also participates in regulating various biological processes such as cell metabolism, signal transduction, and cell proliferation. During the occurrence and development of tumors, imbalance of potassium ion balance is an important factor. Therefore, the role of RELCH in the regulation of potassium channels provides an important theoretical basis for studying the role of potassium ions in tumor occurrence and development. By detecting the RELCH genotype, we can understand the potassium ion concentration in tumor patients and provide an important reference for formulating reasonable treatment plans for tumor patients. RELCH has broad application prospects in the field of cancer and is a potential drug target or biomarker.

Protein Name: RAB11 Binding And LisH Domain, Coiled-coil And HEAT Repeat Containing

Functions: Regulates intracellular cholesterol distribution from recycling endosomes to the trans-Golgi network through interactions with RAB11 and OSBP (PubMed:29514919). Functions in membrane tethering and promotes OSBP-mediated cholesterol transfer between RAB11-bound recycling endosomes and OSBP-bound Golgi-like membranes (PubMed:29514919)

The "RELCH Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RELCH comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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