RORC: A Potential Drug Target and Biomarker (G6097)

Target Name: RORC

NCBI ID: G6097

RORC

RORC: A Potential Drug Target and Biomarker

RORC (RZR-GAMMA) is a drug target and potential biomarker that has been identified for its role in the regulation of cellular processes that are crucial for cell survival. The RORC gene, which encodes for a protein known as RORC, has been shown to play a significant role in the development and progression of various diseases, including cancer.

The Identification of RORC as a Potential Drug Target

RORC has been identified as a potential drug target due to its involvement in the regulation of cellular processes that are crucial for cell survival. The RORC gene has been shown to encode for a protein that is involved in the regulation of cell adhesion, migration, and the association with the cytoskeleton. These processes are critical for the development and progression of various diseases, including cancer.

The Role of RORC in Cellular Processes

RORC is involved in the regulation of several cellular processes that are crucial for cell survival. One of the most significant functions of RORC is its role in the regulation of cell adhesion. This process is critical for the development and maintenance of tissues and organs, and it is also involved in the regulation of embryonic development.

RORC has also been shown to be involved in the regulation of cell migration. This process is critical for the development and progression of various diseases, including cancer. During the cell migration process, RORC has been shown to play a role in the regulation of the cytoskeleton, which is the structure that gives shape to the cell.

In addition to its role in cell adhesion and migration, RORC has also been shown to be involved in the regulation of several other cellular processes that are crucial for cell survival. This includes the regulation of cell signaling pathways, the regulation of gene expression, and the regulation of cellular signaling pathways that are critical for cell survival.

The Potential of RORC as a Drug Target

The identification of RORC as a potential drug target has significant implications for the development of new treatments for various diseases. RORC has been shown to play a role in the regulation of cellular processes that are crucial for cell survival, and targeting RORC has the potential to provide new insights into the mechanisms of various diseases.

One of the key advantages of targeting RORC is its potential to target a wide range of diseases, including cancer. RORC has been shown to play a role in the regulation of cellular processes that are critical for the development and progression of cancer, and targeting RORC has the potential to provide new insights into the mechanisms of cancer.

In addition to its potential as a cancer treatment, RORC has also been identified as a potential biomarker for several diseases. The regulation of cellular processes that are crucial for cell survival is a key factor in the development and progression of various diseases, including cancer. Therefore, RORC has the potential to serve as a biomarker for several diseases, including cancer.

Conclusion

RORC has been identified as a drug target and potential biomarker due to its involvement in the regulation of cellular processes that are crucial for cell survival. The RORC gene has been shown to encode for a protein that is involved in the regulation of cell adhesion, migration, and the association with the cytoskeleton. These processes are critical for the development and progression of various diseases, including cancer. Therefore, the identification of RORC as a potential drug target and biomarker has significant implications for the development of new treatments for various diseases.

Protein Name: RAR Related Orphan Receptor C

Functions: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regulator of cellular differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively (PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regulatory regions to modulate their transcriptional expression, depending on the tissue, time and promoter contexts. Regulates the circadian expression of clock genes such as CRY1, BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as BMAL1, CRY1 and NR1D1 itself, resulting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regulation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A (PubMed:19965867). Negative regulator of adipocyte differentiation through the regulation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte size and modulates insulin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modulator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SULT1E1. Also plays a role in the regulation of hepatocyte glucose metabolism through the regulation of G6PC1 and PCK1 (PubMed:19965867). Regulates the rhythmic expression of PROX1 and promotes its nuclear localization (PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity (PubMed:26160376)

The "RORC Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RORC comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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