RPS11: A Potential Drug Target for Cancer (G6205)

Target Name: RPS11

NCBI ID: G6205

RPS11

RPS11: A Potential Drug Target for Cancer

Ribosomal protein S11 (RPS11) is a protein that is expressed in most eukaryotic cells and is involved in protein synthesis. It is a key protein of the 40S ribosome, which is the largest subunit of the ribosome that is responsible for synthesizing proteins from amino acids . RPS11 is a 16-kDa protein that consists of 256 amino acids. It has a characteristic Rossmann-fold structure and is composed of a single domain.

RPS11 is a protein that has been identified as a potential drug target in the field of cancer. Several studies have shown that high levels of RPS11 are associated with poor prognosis in various types of cancer, including breast, ovarian, and colorectal cancers. Additionally, RPS11 has been shown to promote the growth and survival of cancer cells in cell culture and animal models.

One of the reasons for the potential drug targeting of RPS11 is its role in the regulation of cell growth and survival. RPS11 has been shown to play a role in the regulation of cell cycle progression by preventing the G1/S transition and promoting the G0/ G1 transition. This means that RPS11 keeps cells in a state of quiescence, which helps to prevent the cell from dividing and allows for the production of proteins that are necessary for cell growth and survival.

Another potential drug target for RPS11 is its role in the regulation of cell signaling pathways. RPS11 has been shown to play a role in the regulation of several signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. These signaling pathways are involved in the regulation of cell growth, differentiation, and survival, and RPS11 has been shown to regulate the activity of these pathways.

In addition to its role in cell signaling pathways, RPS11 has also been shown to play a role in the regulation of protein synthesis. RPS11 is a key protein of the 40S ribosome, which is responsible for synthesizing proteins from amino acids. This means that RPS11 is involved in the production of proteins that are essential for cell growth and survival.

Given the potential drug targeting of RPS11, there is a need for further research to better understand its role in cancer progression and the development of new treatments. One approach to this research is to study the effects of drugs that target RPS11 on cancer cell growth and survival. This could include studies on the efficacy and mechanisms of drugs that target RPS11, as well as the development of new drugs that specifically target RPS11.

Another approach to studying the potential drug targeting of RPS11 is to use it as a biomarker to predict the outcomes of cancer treatments. This could include the use of RPS11 as a biomarker to predict the response of cancer cells to different treatments, as well as the use of RPS11 as a biomarker to predict the recurrence of cancer after surgery or chemotherapy.

In conclusion, RPS11 is a protein that has been identified as a potential drug target in the field of cancer. Its role in the regulation of cell growth and survival, as well as its role in the regulation of cell signaling pathways, make it an attractive target for drug development. Further research is needed to better understand the effects of drugs that target RPS11 and to develop new treatments for cancer.

Protein Name: Ribosomal Protein S11

Functions: Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)

The "RPS11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RPS11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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