tubulin folding cofactor C: a potential drug target and biomarker

Target Name: TBCC

NCBI ID: G6903

TBCC

tubulin folding cofactor C: a potential drug target and biomarker

Abstract:
Tubulin folding cofactor C (TBCC) is a protein that plays a critical role in the process of tubulin folding, which is a crucial step in the regulation of microtubules in eukaryotic cells. The misfolding of tubulin has been implicated in various diseases, including neurodegenerative disorders, cancer, and developmental defects. Therefore, targeting TBCC has potential as a drug or biomarker. This article summarizes the current understanding of TBCC, its functions, and potential as a drug target or biomarker.

Introduction:
Tubulin is a protein that plays a central role in the regulation of microtubules in eukaryotic cells. It is composed of four subunits that form a ring-shaped structure around the centromere, which is the region of the chromosome that is responsible for proper segregation during cell division. The misfolding of tubulin has been implicated in various diseases, including neurodegenerative disorders, cancer, and developmental defects. Therefore, the study of TBCC, a protein that plays a critical role in the regulation of tubulin folding, is of great interest.

Current understanding of TBCC:
TBCC is a protein that is expressed in a variety of tissues and cells, including brain, spinal cord, and muscle. It is highly conserved, with a high degree of sequence identity across different species. TBCC has been shown to play a critical role in the regulation of tubulin folding by promoting the process of \"self-assembly\" of the subunits.

In addition to its role in tubulin folding, TBCC has also been shown to play a critical role in the regulation of microtubule dynamics and stability. TBCC has been shown to interact with the microtubule protein TIP60 and with the protein responsible for regulating microtubule stability, MATN3.

Potential as a drug target or biomarker:
The misfolding of tubulin has been implicated in various diseases, including neurodegenerative disorders, cancer, and developmental defects. Therefore, targeting TBCC has potential as a drug or biomarker. If TBCC is found to be involved in the regulation of tubulin folding, then targeting it with drugs that interfere with its function could be a promising strategy for the treatment of diseases caused by misfolded tubulin.

Furthermore, if TBCC is found to be a potential biomarker for monitoring the effectiveness of drugs that target tubulin folding, then it could be used as a predictive tool for drug response in patients with neurodegenerative disorders or other diseases.

Conclusion:
TBCC is a protein that plays a critical role in the regulation of tubulin folding, a crucial step in the regulation of microtubules in eukaryotic cells. The misfolding of tubulin has been implicated in various diseases, including neurodegenerative disorders, cancer, and developmental defects. Therefore, targeting TBCC has potential as a drug target or biomarker. Further research is needed to fully understand its functions and potential as a drug or biomarker.

Protein Name: Tubulin Folding Cofactor C

Functions: Tubulin-folding protein; involved in the final step of the tubulin folding pathway

The "TBCC Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TBCC comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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