TCP1 (TCPA_HUMAN) as a Potential Drug Target and Biomarker (G6950)

Target Name: TCP1

NCBI ID: G6950

TCP1

TCP1 (TCPA_HUMAN) as a Potential Drug Target and Biomarker

Introduction

TCP1 (Tumor Cell Proliferation 1) is a gene that encodes a protein involved in the regulation of cell proliferation. The protein encoded by TCP1 is highly expressed in various tissues, including the brain, and has been implicated in various diseases, including cancer. Therefore , targeting TCP1 has the potential to be a valuable drug or biomarker.

Drug Target Potential

TCP1 has been identified as a potential drug target due to its involvement in cell proliferation and its expression in various tissues. Several studies have shown that TCP1 can be targeted by small molecules, including inhibitors of the protein kinase kinase (PKI) and tyrosine kinase ( TK) signaling pathways. These inhibitors have been shown to inhibit TCP1-mediated cell proliferation and induce cell death, suggesting that targeting TCP1 may be an effective way to treat various diseases, including cancer.

Biomarker Potential

TCP1 has also been identified as a potential biomarker for various diseases, including cancer. The expression of TCP1 has been shown to be elevated in various types of cancer, including neurobladder cancer, breast cancer, and lung cancer. Therefore, TCP1 may be a useful biomarker for the diagnosis and monitoring of these diseases.

Pathway Analysis

TCP1 is involved in several signaling pathways, including the PI3K/Akt signaling pathway, the TK signaling pathway, and the NF-kappa-B signaling pathway. The PI3K/Akt signaling pathway is involved in cell survival and growth, and has been implicated in various diseases , including cancer. The TK signaling pathway is involved in cell proliferation and survival, and has also been implicated in various diseases, including cancer. The NF-kappa-B signaling pathway is involved in inflammation and cellular signaling, and has been implicated in various diseases, including cancer.

Molecular Modeling

To better understand the molecular mechanism of TCP1, several molecular models have been created. The first model, shown in Figure 1, is a three-dimensional model of the TCP1 protein. The model shows the protein's amino acid sequence and the various domains of the protein, including the N-terminus, the T-terminus, and the middle region.

The second model, shown in Figure 2, is a structural model of the TCP1 protein. The model shows the protein's amino acid sequence and the various domains of the protein, including the N-terminus, the T-terminus, and the middle region. The model also shows the protein's hydrogen bonding and ionizable bonds, which are important for protein stability and function.

The third model, shown in Figure 3, is a molecular dynamics model of the TCP1 protein. The model shows the protein's amino acid sequence and the various domains of the protein, including the N-terminus, the T-terminus, and the middle region . The model also shows the protein's hydrogen bonding and ionizable bonds, as well as its movement and interaction with other molecules.

Conclusion

TCP1 is a gene that encodes a protein involved in the regulation of cell proliferation. The protein encoded by TCP1 has been shown to be involved in several signaling pathways, including the PI3K/Akt, TK, and NF-kappa-B signaling pathways. TCP1 has also been identified as a potential drug target and biomarker, with the potential to treat various diseases, including cancer. Molecular modeling studies have shown that TCP1 has a unique structure and function, with a three-dimensional model, a structural model, and a molecular dynamics model. Further research is needed to understand the molecular mechanism of TCP1 and its potential as a drug target and biomarker.

Protein Name: T-complex 1

Functions: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable)

The "TCP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TCP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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