TBX3: A Potential Drug Target Or Biomarker (G6926)

Target Name: TBX3

NCBI ID: G6926

TBX3

TBX3: A Potential Drug Target Or Biomarker

TBX3 (TBX3-ISO) is a protein that is expressed in various tissues of the body, including the lungs, heart, kidneys, and intestines. It is a member of the transforming growth factor beta (TGF-β) family, which is a group of proteins that play a critical role in cell growth, differentiation, and repair.

One of the interesting aspects of TBX3 is its potential as a drug target or biomarker. The TGF-β system has been implicated in the development and progression of many diseases, including cancer, cardiovascular disease, and autoimmune disorders. Therefore, targeting TBX3 or its Downstream targets could potentially lead to new treatments for these diseases.

TBX3 has been shown to play a role in several biological processes in the body, including cell proliferation, apoptosis, angiogenesis, and immune response. It has been shown to regulate cell proliferation by controlling the activity of the TGF-β signaling pathway. This pathway is a complex network of proteins that work together to regulate cell growth and differentiation.

One of the key components of the TGF-β network is the transcription factor SMAD, which is a protein that plays a critical role in regulating gene expression. SMAD has been shown to physically interact with TBX3 and has been shown to play a role in the regulation of TBX3 expression.

Another key component of the TGF-β network is the protein kinase-activated receptor, which is a protein that is activated by the TGF-β signaling pathway. TBX3 has been shown to interact with several of these receptors and has been shown to play a role in the regulation of cellular processes such as cell adhesion, migration, and invasion.

TBX3 has also been shown to play a role in the regulation of the immune response. It has been shown to regulate the production of immune cells in the body and has been shown to play a role in the regulation of inflammation.

In addition to its role in cell signaling processes, TBX3 has also been shown to have several potential clinical applications. For example, it has been shown to be a potential therapeutic target for cancer, as it has been shown to inhibit the growth of cancer cells in cell culture and animal models. It has also been shown to be a potential biomarker for several diseases, including cancer and cardiovascular disease.

TBX3 is also a good candidate as a drug target because of its unique structure and its location in the body. Unlike many other proteins, TBX3 is localized to a single gene and is highly conserved across different species. This makes it easier to identify and manipulate its function.

In conclusion, TBX3 is a protein that has been shown to play a critical role in several biological processes in the body. Its potential as a drug target or biomarker makes it an attractive target for researchers to investigate further. Further studies are needed to fully understand its function and its potential as a therapeutic agent.

Protein Name: T-box Transcription Factor 3

Functions: Transcriptional repressor involved in developmental processes (PubMed:10468588). Binds to the palindromic T site 5'-TTCACACCTAGGTGTGAA-3' DNA sequence, or a half-site, which are present in the regulatory region of several genes (PubMed:12000749). Probably plays a role in limb pattern formation (PubMed:10468588). Required for mammary placode induction, and maintenance of the mammary buds during development (By similarity). Involved in branching morphogenesis in both developing lungs and adult mammary glands, via negative modulation of target genes; acting redundantly with TBX2 (By similarity). Required, together with TBX2, to maintain cell proliferation in the embryonic lung mesenchyme; perhaps acting downstream of SHH, BMP and TGFbeta signaling (By similarity). Involved in modulating early inner ear development, acting independently of, and also redundantly with, TBX2 in different subregions of the developing ear (By similarity). Acts as a negative regulator of PML function in cellular senescence (PubMed:22002537)

The "TBX3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TBX3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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