TEAD2: A Potential Cancer Target Or Biomarker (G8463)

Target Name: TEAD2

NCBI ID: G8463

TEAD2

TEAD2: A Potential Cancer Target Or Biomarker

TEAD2 (Tumor suppressor gene 2) is a gene that has been identified as a potential drug target or biomarker for various diseases, including cancer. The TEAD2 gene is located on chromosome 1p36 and has been shown to play a role in the development and progression of several types of cancer.

The TEAD2 gene is a tumor suppressor gene, which means it is responsible for preventing the formation of cancer cells. It is thought to work by regulating the cell cycle, which is the process by which cells grow and divide. When the cell cycle is properly Regulated, cells are able to divide and grow in a controlled manner, but when it is disrupted or abnormal, cells can start to multiply out of control and form cancer.

TEAD2 is a key gene that has been shown to be involved in the regulation of the cell cycle in various types of cancer. Studies have shown that TEAD2 can be expressed at different levels in cancer cells than in normal cells, and that it is involved in the regulation of cell division. This suggests that TEAD2 may be a useful target for cancer therapies that work by inhibiting the cell cycle.

Another potential mechanism by which TEAD2 may be involved in cancer development is through its role in cell signaling. Oncogenes are genes that promote the growth and division of cancer cells, and TEAD2 is thought to be involved in the regulation of these oncogenes. Studies have shown that TEAD2 can interact with several oncogenes, including the protein kinase A1 (PPKG1), which is known to promote the growth and survival of cancer cells.

In addition to its potential role in cancer development, TEAD2 may also be a useful biomarker for tracking disease progression. Studies have shown that TEAD2 levels can be affected by a variety of factors, including cancer treatment, which suggests that it may be a useful indicator of disease severity and response to treatment.

Overall, TEAD2 is a gene that has the potential to be a drug target or biomarker for various types of cancer. Further research is needed to fully understand its role in cancer development and progression.

Protein Name: TEA Domain Transcription Factor 2

Functions: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif

The "TEAD2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TEAD2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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