BUB1: A Protein with Multiple Functions in The Body (G699)

Target Name: BUB1

NCBI ID: G699

BUB1

BUB1: A Protein with Multiple Functions in The Body

BUB1 (BUB1A) is a protein that is expressed in various tissues of the body, including the brain, heart, and gastrointestinal tract. It is a member of the Tetraspanin family, which are a group of proteins that are known for their role in organizing various signaling pathways in cells.

One of the most significant functions of BUB1 is its role in cell signaling. BUB1 is involved in the regulation of various signaling pathways, including the TGF-β pathway, which is a well-known signaling pathway that is involved in the development and maintenance of tissues.

BUB1 is also involved in the regulation of cell adhesion and migration. It has been shown to play a role in the regulation of tight junction formation, which is the process by which cells stick together to form tissues and organs.

In addition to its role in cell signaling and cell adhesion, BUB1 is also involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune cell function, and has been shown to contribute to the development of various inflammatory diseases.

Despite its involvement in a number of important cellular processes, BUB1 is not well understood. little is known about the underlying biology of BUB1, and it is not clear what the full range of its functions is.

In conclusion, BUB1 is a protein that is involved in a number of important cellular processes in the body. While more research is needed to fully understand its role in these processes, it is clear that BUB1 is a promising drug target and may have a variety of potential therapeutic applications in the future.

Protein Name: BUB1 Mitotic Checkpoint Serine/threonine Kinase

Functions: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (PubMed:35044816). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

The "BUB1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about BUB1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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