LINC00472: A Potential Drug Target and Biomarker for Neurological Disorders

Target Name: LINC00472

NCBI ID: G79940

LINC00472

Other Name(s): DJ288M22.3 | P53RRA | Long intergenic non-protein coding RNA 472, transcript variant 2 | long intergenic non-protein coding RNA 472 | C6orf155

LINC00472: A Potential Drug Target and Biomarker for Neurological Disorders

LINC00472 (DJ288M22.3) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the LINC family of proteins, which are known for their role in intracellular signaling. LINC00472 has been shown to play a role in the regulation of cellular processes that are important for brain function, such as the formation of new neurons and the regulation of neurotransmitter release.

One of the unique features of LINC00472 is its ability to interact with multiple protein partners, including the protein known as DJ288M22.DJ2, which is a key regulator of the microtubule network. DJ288M22 is known for its role in the regulation of cell division, and LINC00472 has been shown to interact with DJ288M22 in a way that affects the formation of new neurons and the growth of neural tissues.

In addition to its role in cell signaling, LINC00472 is also of interest as a potential drug target. Several studies have shown that LINC00472 can be inhibited by small molecules, such as those that target the activity of DJ288M22. This suggests that LINC00472 may be a useful target for the development of new treatments for a variety of neurological and psychiatric disorders.

One of the challenges in studying LINC00472 as a drug target is its complex structure. LINC00472 is a protein that is expressed in a variety of tissues and has a highly conserved amino acid sequence. This makes it difficult to predict the exact structure of the protein and identify potential binding sites. However, several studies have used techniques such as yeast two-hybrid assays and protein fragment complementation assays to identify potential binding sites on DJ288M22 and to study the interactions between LINC00472 and DJ288M22.

In addition to its potential as a drug target, LINC00472 is also of interest as a potential biomarker for certain neurological disorders. Several studies have shown that LINC00472 is expressed in the brains of individuals with certain psychiatric disorders, such as depression and anxiety. This suggests that LINC00472 may be a useful biomarker for these disorders and that its levels may be relevant to the diagnosis and treatment of these conditions.

Overall, LINC00472 is a protein that has the potential to be a drug target and a biomarker for a variety of neurological and psychiatric disorders. Further research is needed to fully understand its role and to develop new treatments based on its properties.

Protein Name: Long Intergenic Non-protein Coding RNA 472

The "LINC00472 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC00472 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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