CXCL10: A Potential Drug Target and Biomarker for Interferon-Inducible cytokine IP-10

Target Name: CXCL10

NCBI ID: G3627

CXCL10

CXCL10: A Potential Drug Target and Biomarker for Interferon-Inducible cytokine IP-10

Interferon-inducible cytokine IP-10 (CXCL10) is a protein that plays a critical role in the regulation of immune responses and inflammation. It is a member of the CXCR4 family, which includes several cytokines, including IP-10, IP-11, and IP-18. IP-10 is a potent cytokine that can induce the production of various cytokines and chemokines, including Th2 cytokines, which are important drivers of inflammation and immune responses.

CXCL10 is involved in the regulation of T cell development and function, as well as the regulation of immune cell proliferation and differentiation. It is expressed in a variety of tissues and cells, including the skin, hair, and nervous system, and has been implicated in the development and progression of several diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

One of the key functions of IP-10 is its ability to induce the production of pro-inflammatory cytokines. IP-10 can activate several transcription factors, including NF-kappa-B, which is a key regulator of inflammation and immune responses. Activated NF-kappa-B signaling leads to the production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6. These cytokines play important roles in the regulation of immune responses, including the regulation of inflammation, cell survival, and apoptosis.

In addition to its role in the regulation of cytokine production, IP-10 is also involved in the regulation of cellular signaling pathways that are important for cellular survival and proliferation. IP-10 has been shown to play a role in the regulation of the PI3K/Akt signaling pathway, which is important for the regulation of cellular signaling pathways that are involved in cell survival, angiogenesis, and inflammation.

Given its involvement in the regulation of cytokine production and cellular signaling pathways, IP-10 is a potential drug target for the treatment of a variety of diseases. For example, IP-10 has been shown to be involved in the regulation of the development and progression of cancer, and may be a useful target for the treatment of cancer. Additionally, IP-10 has been implicated in the regulation of autoimmune disorders, and may be a useful target for the treatment of these disorders.

In addition to its potential therapeutic applications, IP-10 is also a potential biomarker for the diagnosis and monitoring of several diseases. For example, IP-10 has been shown to be involved in the regulation of inflammation, and may be a useful biomarker for the assessment of inflammation in a variety of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

Given its involvement in the regulation of cytokine production and cellular signaling pathways, IP-10 is a promising target for the development of new therapeutic agents for the treatment of a variety of diseases. Further research is needed to fully understand the role of IP-10 in disease and to develop effective treatments based on this promising target.

Protein Name: C-X-C Motif Chemokine Ligand 10

Functions: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:7540647, PubMed:11157474, PubMed:22652417). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12750173, PubMed:12663757). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity)

The "CXCL10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CXCL10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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