Understanding CTPS2: Potential Drug Target Or Biomarker (G56474)

Target Name: CTPS2

NCBI ID: G56474

CTPS2

Understanding CTPS2: Potential Drug Target Or Biomarker

CTPS2 (PYRG2_HUMAN), a protein that belongs to the CTPS2 gene family, has been identified as a potential drug target or biomarker in various diseases, including cancer, cardiovascular disease, and neurological disorders. Its unique structure and function have made it an attractive target for researchers to study, and several studies have investigated its role in these conditions.

The CTPS2 gene is located on chromosome 12p36 and encodes a protein that is involved in various cellular processes, including cytoskeletal organization, cell adhesion, and signaling pathways. The protein has four known isoforms, which are different in their size and localization to different cellular compartments. The most abundant is the CTPS2-long isoform, which is predominantly located in the cytoplasm and is involved in the formation of tight junctions, which are a type of cell-cell adhesion. The other three isoforms are predominantly located in the pericellular environment and are involved in different cellular processes, including the regulation of cell division and the assembly of organelles.

Recent studies have suggested that CTPS2 may be involved in various diseases, including cancer, cardiovascular disease, and neurological disorders. For example, several studies have shown that high levels of CTPS2 are associated with poor prognosis in cancer patients. In addition, research has also suggested that CTPS2 may be involved in the development of cardiovascular disease, including myocardial infarction and stroke.

One of the key features of CTPS2 is its ability to interact with various signaling pathways. The protein has been shown to interact with several signaling pathways, including TGF-β, NF-kappa-B, and PI3K/AKT. These signaling pathways are involved in various cellular processes, including cell growth, differentiation, and inflammation. Interactions with these signaling pathways may explain some of the functions of CTPS2.

In addition to its role in signaling pathways, CTPS2 has also been shown to play a role in the regulation of cellular processes that are important for maintaining cellular organization and stability. For example, studies have shown that CTPS2 is involved in the regulation of cell division, and that it plays a role in the assembly and disassembly of tight junctions.

Furthermore, recent studies have suggested that CTPS2 may be involved in the regulation of cellular processes that are important for maintaining cellular homeostasis. For example, research has shown that CTPS2 is involved in the regulation of cytoskeletal organization, and that it plays a role in the maintenance of cell shape.

In conclusion, CTPS2 is a protein that has been shown to be involved in various cellular processes that are important for maintaining cellular organization and stability. Its unique structure and function make it an attractive target for researchers to study, and several studies have suggested that it may be involved in various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is needed to fully understand the role of CTPS2 in these conditions, and to develop effective therapies that target this protein.

Protein Name: CTP Synthase 2

Functions: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides

The "CTPS2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CTPS2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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