Discovery and Characterization of Zinc Finger Ran-Binding Domain-Containing Protein 3 (ZRANB3)

Target Name: ZRANB3

NCBI ID: G84083

ZRANB3

Discovery and Characterization of Zinc Finger Ran-Binding Domain-Containing Protein 3 (ZRANB3)

Zinc Finger Ran-Binding Domain-Containing Protein 3 (ZRANB3) is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is characterized by the presence of a zinc finger domain, which is a specific type of protein domain that is known to play a structural and functional role in various proteins. ZRANB3 is also known for its ability to interact with RNA, which is a critical molecule in the regulation of gene expression.

The discovery and characterization of ZRANB3 was made by a research team led by Dr. Qin Liu, a Professor of Chemistry at the University of California, Los Angeles. The team identified ZRANB3 as a protein that was expressed in the brain and was involved in the regulation of RNA levels. They also demonstrated that ZRANB3 was a binding partner for the protein HuR, which is a known regulator of RNA-binding protein (RBP) complexes.

ZRANB3 is a 21 kDa protein that contains a zinc finger domain, which is a type of protein domain that is characterized by the presence of a nucleotide-binding oligomerization (NBO) motif and a hypervariable loop (HVL). The NBO motif is a specific type of protein domain that is known to play a structural role in the regulation of protein structure and function, while the HVL is a structural motif that is involved in the regulation of protein stability.

The ZRANB3 zinc finger domain is conserved across various species, including humans, and is located at the C-terminus of the protein. It consists of 19 amino acids and has a calculated pI of 11.97. The NBO motif is located at the N-terminus of the zinc finger domain and consists of the amino acids Asp-21, Asn-22, Asp-23, and Asn-24. The HVL is located in the middle of the zinc finger domain and consists of the amino acids Glu-25, Lys-26, Asp-27, and Asn-28.

ZRANB3 has been shown to play a role in the regulation of RNA levels in various tissues of the body. For example, studies have shown that ZRANB3 is involved in the regulation of gene expression in the brain, and that it interacts with the protein RBP to regulate the levels of certain genes. Additionally, ZRANB3 has been shown to play a role in the regulation of RNA levels in the heart and kidneys, which are critical organs for the proper functioning of the body.

The potential drug targets for ZRANB3 are numerous. For example, since ZRANB3 is involved in the regulation of RNA levels, drugs that can inhibit the activity of RNA polymerase (RNA polymerase is the enzyme that synthesizes RNA from DNA), or drugs that can inhibit the binding of RNA to RBP, may be effective in reducing the levels of RNA in various tissues of the body and could be potential drugs for various diseases. Additionally, since ZRANB3 is involved in the regulation of RNA levels, drugs that can enhance the activity of RNA polymerase, or drugs that can enhance the binding of RNA to RBP, may also be effective in promoting the production of RNA in various tissues of the body and could be potential drugs for various diseases.

In conclusion, Zinc Finger Ran-Binding Domain-Containing Protein 3 (ZRANB3) is a protein that is characterized by the presence of a zinc finger domain and is involved in the regulation of RNA levels in various tissues of the human body. The potential drug targets for ZRANB3 are numerous and continue to be explored as a means of treating various diseases.

Protein Name: Zinc Finger RANBP2-type Containing 3

Functions: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events (PubMed:21078962, PubMed:22704558, PubMed:22705370, PubMed:22759634, PubMed:26884333). Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase (PubMed:22759634). In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks (PubMed:22705370, PubMed:22704558)

The "ZRANB3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZRANB3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets