Understanding ACTN1: Potential Drug Target and Biomarker (G87)

Target Name: ACTN1

NCBI ID: G87

ACTN1

Understanding ACTN1: Potential Drug Target and Biomarker

ACTN1 (Actinin-1), also known as ACTN1 variant 1, is a protein that is expressed in most tissues of the body. It is a key component of the actin filament, which is a structure that makes up the cytoskeleton of eukaryotic cells. In this article, we will discuss the biology of ACTN1, its function in cell signaling, and its potential as a drug target or biomarker.

Biochemistry and Structure

ACTN1 is a 21-kDa protein that is composed of 155 amino acid residues. It has a characteristic Rossmann-fold structure that is composed of a parallel beta-sheet and a parallel alpha-helices. The protein has a distinct N-terminal and C -terminal region, which are involved in its stability and localization to the cytoskeleton.

Function

ACTN1 plays a critical role in cell signaling, particularly in the regulation of cell division and cytoskeletal organization. It is a key component of the microtubules, which are the subunits of the cytoskeleton that provide structural support and mechanical stability to the cell. ACTN1 is involved in the regulation of microtubule dynamics and stability, which is essential for cell division and cytoskeletal organization.

In addition to its role in cytoskeletal organization, ACTN1 is also involved in the regulation of cell signaling pathways. It has been shown to be involved in the regulation of cell cycle progression, cell division, and apoptosis. ACTN1 has also been shown to play a role in the regulation of angiogenesis, which is the process by which new blood vessels are formed.

Drug Target and Biomarker

ACTN1 is a potential drug target because of its involvement in cell signaling pathways. Many diseases are caused by the disruption of normal cell signaling pathways, including cancer, neurodegenerative diseases, and developmental disorders. ACTN1 has been shown to be involved in the regulation of multiple signaling pathways, including the regulation of cell cycle progression, cell division, apoptosis, and angiogenesis.

ACTN1 has also been shown to be a potential biomarker for several diseases, including cancer, neurodegenerative diseases, and developmental disorders. Its expression has been shown to be elevated in a variety of cancer types, including breast, ovarian, and colorectal cancers. It has has also been shown to be elevated in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Conclusion

In conclusion, ACTN1 is a protein that is involved in the regulation of cell signaling pathways and plays a critical role in the organization and stability of the cytoskeleton. Its function in cell signaling and its potential as a drug target or biomarker make it an attractive target for future research. Further studies are needed to fully understand the role of ACTN1 in cell signaling and its potential as a drug target or biomarker.

Protein Name: Actinin Alpha 1

Functions: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein

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