FADD: A Potential Drug Target and Biomarker for FAS-Associated Death Domain-Containing Protein

Target Name: FADD

NCBI ID: G8772

FADD

FADD: A Potential Drug Target and Biomarker for FAS-Associated Death Domain-Containing Protein

Abstract:

FAS-associating death domain-containing protein (FADD) is a protein that has been identified as a potential drug target and biomarker for various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. FADD is a protein that is expressed in various tissues and cells, including brain, heart, and blood vessels, and is known for its role in cell signaling and inflammation. Recent studies have suggested that FADD may be involved in a wide range of physiological processes, including cell survival, migration, and inflammation. This article will review the current state of research on FADD, including its potential drug target and biomarker properties, and highlight some of the recent findings that have shed light on its role in disease.

Introduction:

FAS (fas) is a family of transmembrane proteins that play a central role in cell signaling and inflammation. FAS-associating death domain-containing protein (FADD) is a specific type of FAS protein that is known for its ability to interact with and modulate the activity of other FAS proteins. FADD has been shown to be involved in a wide range of physiological processes, including cell survival, migration, and inflammation.

Potential Drug Target and Biomarker Properties:

FADD has been identified as a potential drug target due to its involvement in various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. One of the reasons for its potential as a drug target is its ability to modulate the activity of other FAS proteins, which can potentially create a feedback loop that regulates cell signaling and inflammation. Additionally, FADD has been shown to be involved in the regulation of cellular processes that are important for cancer progression, such as cell division, angiogenesis, and immune evasion.

FADD has also been identified as a potential biomarker for various diseases, including neurodegenerative disorders, cancer, and autoimmune diseases. Its expression has been shown to be associated with a wide range of diseases, including Alzheimer's disease, Parkinson's disease, and multiple sclerosis. Additionally, FADD has been shown to be involved in the regulation of cellular processes that are important for disease progression, such as cancer cell growth and immune evasion.

FADD Interactions with Other Proteins:

FADD has been shown to interact with a wide range of other proteins, including FAS, PDZP2, and NF-kappa-B. These interactions have the potential to modulate the activity of these proteins and may be involved in the regulation of various cellular processes, including cell survival, migration, and inflammation.

FADD's Role in Cell Survival and Migration:

Several studies have shown that FADD is involved in the regulation of cell survival and migration. For example, one study published in the journal PLoS found that FADD was able to modulate the activity of Bcl-2, a protein that is known to play a role in cell survival and proliferation. Additionally, another study published in the journal Nature found that FADD was involved in the regulation of cell migration, as demonstrated by its ability to interact with the protein vimentin.

FADD's Role in Inflammation:

FADD has also been shown to be involved in the regulation of inflammation. One study published in the journal Inflammation found that FADD was involved in the regulation of inflammation by modulating the activity of various cytokines, including TNF-伪 and IL-1尾. Additionally, another study published in the journal Molecular Psychiatry found that FADD was involved in the regulation of anxiety and stress, as demonstrated by its ability to modulate the activity of GABA

Protein Name: Fas Associated Via Death Domain

Functions: Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors (PubMed:7538907, PubMed:23955153, PubMed:19118384, PubMed:20935634, PubMed:16762833, PubMed:24025841). The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation (PubMed:7538907, PubMed:19118384, PubMed:20935634, PubMed:16762833). Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis (PubMed:16762833). Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling (PubMed:21109225)

The "FADD Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FADD comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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