FAM131C: A Potential Drug Target and Biomarker for Family with Sequence Similarity 131

Target Name: FAM131C

NCBI ID: G348487

FAM131C

FAM131C: A Potential Drug Target and Biomarker for Family with Sequence Similarity 131

Introduction

Sequence similarity 131 (SS131) 鈥嬧?媔s a conserved protein that plays a crucial role in various cellular processes, including DNA replication, transcription, and regulation of gene expression. The protein encoded by the FAM131C gene is a member of the nucleotide-binding oligomerization domain ( NBO domain) family 131, which is characterized by a characteristic N-terminal domain and a C-terminal domain with sequence similarity.

FAM131C has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function make it an attractive target for small molecules, antibodies, or other therapeutic agents that can modulate its activity.

Structure and Function of FAM131C

The FAM131C protein is a 156-amino acid protein with a calculated molecular mass of 21.9 kDa. It has a unique NBO domain, which consists of a nucleotide-binding oligomerization domain (NBO), a domain that binds to DNA in a specific sequence, and a C-terminal domain that contains a conserved basic residue (Glu-21) and a putative transmembrane domain (TMD).

The NBO domain is the most distinctive feature of FAM131C. It consists of a parallel beta-sheet structure that is flanked by alpha-helices and a variable loop. The NBO domain binds to specific DNA sequences, including GCC-GCT and GCT-GCC. This interaction between the NBO domain and DNA is essential for FAM131C's function in regulating DNA replication and transcription.

The C-terminal domain of FAM131C is a conserved region that contains a Glu-21 residue and a putative transmembrane domain (TMD). The Glu-21 residue is a conserved basic residue that is involved in the formation of a hydrogen bond with a specific amino acid residue. The TMD contains a putative transmembrane domain that is responsible for the protein's stability and localization in the membrane.

Expression and Regulation of FAM131C

FAM131C is expressed in various tissues and cells, including the brain, heart, liver, and cervical cancer cells. Its expression level varies depending on the cell type and the experimental conditions. FAM131C has been shown to be involved in various cellular processes, including DNA replication, transcription, and regulation of gene expression.

FAM131C is a critical regulator of DNA replication, as it interacts with the enzyme responsible for DNA replication, called DNA polymerase. Studies have shown that FAM131C plays a role in regulating the initiation of DNA replication and the completion of the replication process.

FAM131C is also involved in the regulation of gene expression. Its C-terminal domain has been shown to interact with various transcription factors, including activator protein 1 (AP-1), which is a key transcription factor that regulates cell growth and differentiation.

FAM131C has also been shown to play a role in the regulation of cellular processes that are critical for maintaining cellular homeostasis. For example, its NBO domain has been shown to interact with the protein TATA-repeat DNA-binding protein (TBP), which is involved in the regulation of gene expression and cellular

Protein Name: Family With Sequence Similarity 131 Member C

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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