DNAI4 Plays A Crucial Role in DNA Replication and Repair (G79819)

Target Name: DNAI4

NCBI ID: G79819

DNAI4

DNAI4 Plays A Crucial Role in DNA Replication and Repair

DNAI4 (DNAI4_HUMAN), also known as human doublestranded DNA-binding protein 4, is a protein that plays a crucial role in the regulation of DNA replication and repair in the human body. It is a key component of the complex protein complex known as the A mitochondrial DNA replication complex (IDR), which is responsible for copying the DNA of the cell during cell division.

DNAI4 is a 22kDa protein that consists of 115 amino acid residues. It has a unique structure that allows it to interact with DNA in a specific way. Specifically, DNAI4 can form a stable complex with DNA in the double-stranded state, while also being able to recognize and bind to single-stranded DNA. This dual ability to interact with both single-stranded and double-stranded DNA makes DNAI4 an ideal protein target for drugs that aim to modulate DNA replication or repair.

One of the key functions of DNAI4 is its role in DNA repair. DNAI4 has been shown to be involved in the repair of DNA double-strand breaks, which are a common type of genetic damage that can occur during DNA replication. These breaks can occur due to a variety of factors, including errors in DNA replication, exposure to radiation, or chemical stress. When a double-strand break occurs, DNAI4 is able to recognize the damage and repair it.

Another important function of DNAI4 is its role in DNA replication. DNAI4 is a key component of the IDR, which is responsible for copying the DNA of the cell during cell division. Specifically, DNAI4 helps to ensure that the IDR origin of replication has the correct damage repair, ensuring that each new cell has a complete set of chromosomes.

In addition to its role in DNA replication and repair, DNAI4 has also been shown to play a key role in the regulation of DNA binding proteins. DNAI4 has been shown to interact with a variety of DNA-binding proteins, including the protein p53. This interaction between DNAI4 and p53 allows p53 to effectively repair DNA double-strand breaks that occur during the IDR.

Furthermore, DNAI4 is also known to play a role in the regulation of cell cycle progression. It is research showing that DNAI4 helps to control the entry of cells into the G1 phase of the cell cycle, which is a critical stage in the cell cycle where Cells prepare for DNA replication and cell division.

In conclusion, DNAI4 is a protein that plays a crucial role in the regulation of DNA replication and repair in the human body. Its ability to form a stable complex with DNA in both single-stranded and double-stranded states, as well as its role in DNA repair and replication, make DNAI4 an attractive protein target for drugs that aim to modulate these processes. Furthermore, its role in the regulation of cell cycle progression also adds another layer of significance for its function as a drug target.

Protein Name: Dynein Axonemal Intermediate Chain 4

Functions: Plays a critical role in the assembly of axonemal dynein complex, thereby playing a role in ciliary motility

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