MICU1: A Protein Regulating Mitochondrial Function and Calcium Homeostasis
MICU1: A Protein Regulating Mitochondrial Function and Calcium Homeostasis
MICU1 (Mitochondrial Calcium Uptake 1) is a protein that plays a crucial role in the regulation of mitochondrial function and calcium homeostasis. It is composed of two subunits, MICU1A and MICU1B, which are located in the cytoplasm and mitochondrial inner membrane, respectively. MICU1 is involved in the uptake of calcium ions from the cytosol into the mitochondria, where they are involved in various cellular processes, including protein synthesis, energy production, and signaling pathways.
MICU1 is a well-established drug target and has been identified as a potential therapeutic agent for various diseases, including Alzheimer's disease, Parkinson's disease, and cardiovascular disease. The potential mechanism of action of MICU1 is its role in the regulation of mitochondrial function and calcium homeostasis, which are crucial for the survival and proper functioning of nerve and muscle cells.
In the context of Alzheimer's disease, MICU1 has been shown to be overexpressed in the brains of individuals with the disease. This increase in MICU1 expression has been linked to the misfolding and aggregation of beta-amyloid peptides, which are a hallmark of Alzheimer's disease. MICU1 has also been shown to be involved in the regulation of neurotransmitter synthesis and release, and its expression has been implicated in the development of neurodegeneration in the disease.
MICU1 has also been shown to be involved in the regulation of muscle function and posture. It plays a role in the regulation of muscle contractions and has been implicated in the development of muscle weakness and wasting in diseases such as cancer and neurodegenerative disorders.
In addition to its potential therapeutic applications, MICU1 is also an attractive biomarker for the diagnosis and monitoring of various diseases. The misfolding and aggregation of beta-amyloid peptides, which are a hallmark of Alzheimer's disease, can be detected using MICU1 as a potential diagnostic marker. Similarly, MICU1 has been shown to be involved in the regulation of neurotransmitter synthesis and release, which can be used as a potential biomarker for the diagnosis and monitoring of neurodegenerative disorders.
In conclusion, MICU1 is a protein that plays a crucial role in the regulation of mitochondrial function and calcium homeostasis. Its potential therapeutic applications for Alzheimer's disease and other diseases include its role in the regulation of neurotransmitter synthesis and release, as well as its potential use as a biomarker for the diagnosis and monitoring of various diseases. Further research is needed to fully understand the role of MICU1 in these processes and to develop effective therapeutic strategies for its treatment.
Protein Name: Mitochondrial Calcium Uptake 1
Functions: Key regulator of mitochondrial calcium uniporter (MCU) that senses calcium level via its EF-hand domains (PubMed:20693986, PubMed:23101630, PubMed:23747253, PubMed:24313810, PubMed:24332854, PubMed:24503055, PubMed:24560927, PubMed:26341627, PubMed:26903221, PubMed:27099988). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. MICU1 acts both as an activator or inhibitor of mitochondrial calcium uptake (PubMed:26903221). Acts as a gatekeeper of MCU at low concentration of calcium, preventing channel opening (PubMed:26903221). Enhances MCU opening at high calcium concentration, allowing a rapid response of mitochondria to calcium signals generated in the cytoplasm (PubMed:24560927, PubMed:26903221). Regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake (PubMed:22904319). Induces T-helper 1-mediated autoreactivity, which is accompanied by the release of IFNG (PubMed:16002733)
The "MICU1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MICU1 comprehensively, including but not limited to:
• general information;
• protein structure and compound binding;
• protein biological mechanisms;
• its importance;
• the target screening and validation;
• expression level;
• disease relevance;
• drug resistance;
• related combination drugs;
• pharmacochemistry experiments;
• related patent analysis;
• advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai
More Common Targets
MICU2 | MICU3 | MID1 | MID1IP1 | MID1IP1-AS1 | MID2 | MIDEAS | MIDEAS-AS1 | MIDN | MIEF1 | MIEF2 | MIEN1 | MIER1 | MIER2 | MIER3 | MIF | MIF-AS1 | MIF4GD | MIGA1 | MIGA2 | MIIP | MILIP | MILR1 | MIMT1 | MINAR1 | MINAR2 | MINCR | MINDY1 | MINDY2 | MINDY2-DT | MINDY3 | MINDY4 | Minichromosome maintenance (MCM) 2-7 helicase complex | MINK1 | MINPP1 | MIOS | MIOX | MIP | MIPEP | MIPEPP3 | MIPOL1 | MIR1-1 | MIR1-1HG | MIR1-2 | MIR100 | MIR100HG | MIR101-1 | MIR101-2 | MIR10394 | MIR10396B | MIR10399 | MIR103A1 | MIR103A2 | MIR103B1 | MIR103B2 | MIR105-1 | MIR105-2 | MIR10527 | MIR106A | MIR106B | MIR107 | MIR10A | MIR10B | MIR11181 | MIR11400 | MIR11401 | MIR1178 | MIR1179 | MIR1180 | MIR1181 | MIR1182 | MIR1183 | MIR1184-1 | MIR1184-2 | MIR1184-3 | MIR1185-1 | MIR1185-2 | MIR1193 | MIR1197 | MIR1199 | MIR1200 | MIR1202 | MIR1203 | MIR1204 | MIR1205 | MIR1206 | MIR1207 | MIR1208 | MIR12129 | MIR12135 | MIR12136 | MIR122 | MIR1224 | MIR1225 | MIR1226 | MIR1227 | MIR1228 | MIR1229 | MIR1231 | MIR1233-1
