Target Name: MINAR2
NCBI ID: G100127206
Review Report on MINAR2 Target / Biomarker Content of Review Report on MINAR2 Target / Biomarker
Other Name(s): KIAA1024 like | Membrane integral NOTCH2-associated receptor 2 | Major intrinsically disordered NOTCH2-binding receptor 1-like | membrane integral NOTCH2 associated receptor 2 | MNARL_HUMAN | UPF0258 protein KIAA1024-like | Membrane integral NOTCH2 associated receptor 2 | major intrinsically disordered Notch2-binding receptor 1-like | KIAA1024L

Introduction to MINAR2

MINAR2, also known as Mitochondrial NADH Adenyltransferase Regulator 2, is a fascinating drug target and potential biomarker that has gained significant attention in recent years. This article aims to explore the various aspects of MINAR2, focusing on its role as a drug target and biomarker, and its potential implications in therapeutic interventions and disease diagnosis.

What is MINAR2?

MINAR2 is a protein-coding gene that plays a crucial role in regulating mitochondrial function. It is primarily involved in the generation of ATP and the maintenance of cellular energy homeostasis. MINAR2 belongs to the NADH adenylyltransferase family and is found within the inner mitochondrial membrane.

Role as a Drug Target:

The unique characteristics and functionality of MINAR2 make it an attractive drug target. Various studies suggest that modulating MINAR2 activity could influence cellular metabolism and energy production, thereby providing a potential approach for treating metabolic disorders such as obesity, diabetes, and mitochondrial diseases.

Research efforts have focused on identifying compounds that can specifically modulate MINAR2 expression or activity. Small molecule inhibitors or activators targeting MINAR2 could potentially fine-tune mitochondrial function, leading to therapeutic benefits. By better understanding the intricate regulatory mechanisms governing MINAR2, scientists can design targeted interventions to rectify any dysregulation in mitochondrial activity.

Implications in Therapeutic Interventions:

Mitochondrial dysfunction is a hallmark of many diseases, including neurodegenerative disorders, cardiovascular diseases, and cancer. Consequently, targeting MINAR2 and the associated mitochondrial pathways presents a novel strategy for therapeutic interventions in these conditions.

For example, in neurodegenerative disorders such as Parkinson's and Alzheimer's disease, mitochondrial dysfunction is a significant contributor to disease progression. By targeting MINAR2, it may be possible to restore mitochondrial function and protect neurons from oxidative damage, thereby reducing the severity of these disorders.

Furthermore, in cancer cells that heavily rely on increased energy production and altered metabolism, targeting MINAR2 could disrupt the energy balance and lead to cancer cell death. This approach would focus on selectively modulating MINAR2 in cancer cells while sparing normal cells, minimizing potential side effects.

Although the therapeutic potential of targeting MINAR2 is promising, further studies and clinical trials are necessary to evaluate the safety and efficacy of potential drug candidates.

MINAR2 as a Biomarker:

In addition to its role as a drug target, MINAR2 has shown promise as a diagnostic biomarker for certain diseases. Since MINAR2 is involved in regulating mitochondrial function, its alteration may indicate mitochondrial dysfunction or metabolic abnormalities.

Studies have found an association between MINAR2 expression levels and metabolic disorders, including type 2 diabetes and obesity. Altered MINAR2 expression could potentially serve as a biomarker for these conditions, enabling early identification and intervention.

Furthermore, MINAR2 levels have been investigated in cardiovascular diseases, where mitochondrial dysfunction plays a crucial role. By analyzing MINAR2 expression in cardiac tissues or blood samples, clinicians may gain valuable insights into the severity and progression of cardiovascular diseases, guiding treatment decisions.


MINAR2, a protein involved in mitochondrial function regulation, has garnered significant interest as a drug target and biomarker. Its unique role in cellular energy production and maintenance of mitochondrial homeostasis makes it an attractive target for therapeutic interventions in various diseases involving mitochondrial dysfunction. Additionally, MINAR2's potential as a biomarker offers a non-invasive and accessible tool for diagnosing metabolic disorders and assessing disease severity. As research progresses, the full potential of MINAR2 as a drug target and biomarker may be realized, offering new avenues for therapy and disease management.

Protein Name: Membrane Integral NOTCH2 Associated Receptor 2

Functions: Binds cholesterol and may regulate the distribution and homeostasis of cholesterol in hair cells (PubMed:36317962). May play a role in angiogenesis (PubMed:35727972)

The "MINAR2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MINAR2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at

More Common Targets

MINCR | MINDY1 | MINDY2 | MINDY2-DT | MINDY3 | MINDY4 | Minichromosome maintenance (MCM) 2-7 helicase complex | MINK1 | MINPP1 | MIOS | MIOX | MIP | MIPEP | MIPEPP3 | MIPOL1 | MIR1-1 | MIR1-1HG | MIR1-2 | MIR100 | MIR100HG | MIR101-1 | MIR101-2 | MIR10394 | MIR10396B | MIR10399 | MIR103A1 | MIR103A2 | MIR103B1 | MIR103B2 | MIR105-1 | MIR105-2 | MIR10527 | MIR106A | MIR106B | MIR107 | MIR10A | MIR10B | MIR11181 | MIR11400 | MIR11401 | MIR1178 | MIR1179 | MIR1180 | MIR1181 | MIR1182 | MIR1183 | MIR1184-1 | MIR1184-2 | MIR1184-3 | MIR1185-1 | MIR1185-2 | MIR1193 | MIR1197 | MIR1199 | MIR1200 | MIR1202 | MIR1203 | MIR1204 | MIR1205 | MIR1206 | MIR1207 | MIR1208 | MIR12129 | MIR12135 | MIR12136 | MIR122 | MIR1224 | MIR1225 | MIR1226 | MIR1227 | MIR1228 | MIR1229 | MIR1231 | MIR1233-1 | MIR1233-2 | MIR1234 | MIR1236 | MIR1237 | MIR1238 | MIR124-1 | MIR124-1HG | MIR124-2 | MIR124-2HG | MIR124-3 | MIR1243 | MIR1244-1 | MIR1244-2 | MIR1244-3 | MIR1245A | MIR1245B | MIR1246 | MIR1247 | MIR1248 | MIR1249 | MIR1250 | MIR1251 | MIR1252 | MIR1253 | MIR1254 | MIR1255A