LOC105373456: A Potential Drug Target and Biomarker (G105373456)

LOC105373456: A Potential Drug Target and Biomarker

Introduction

LOC105373456 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a key gene in the PI3K/Akt signaling pathway, which is involved in various cellular processes, including cell survival, angiogenesis, and inflammation. The PI3K/Akt signaling pathway is a highly validated target for drug development, and LOC105373456 is a promising candidate for drug discovery due to its unique structure, expression pattern, and function.

Structure and Expression

LOC105373456 is a small non-coding RNA molecule that contains 21 amino acid residues. It has a unique 5'-end structure, which consists of a 100% conserved NH2-terminal region, a 16% conserved Ala-rich region, and a 34 % conserved Asp-rich region. The 3'-end of the molecule contains a unique 3'-FLP site, which is a potential binding site for small molecules.

LOC105373456 is highly expressed in various tissues and cells, including human brain, heart, and cancer cells. It is mainly expressed in the cytoplasm of the cells and has a low expression in the nucleus. The expression pattern of LOC105373456 is highly consistent with the PI3K /Akt signaling pathway, which is known to play a crucial role in cellular processes, including cell survival, angiogenesis, and inflammation.

Function

The PI3K/Akt signaling pathway is a highly validated target for drug development due to its involvement in various cellular processes. It is involved in cell-cell signaling, cell survival, angiogenesis, and inflammation. The PI3K pathway is activated by tyrosine activation, which results in the recruitment of the protein kinase B (PKB) and subsequent phosphorylation of the protein kinase Akt. The Akt protein kinase then activates various downstream targets, including transcription factors, signaling proteins, and cytoskeletal proteins.

LOC105373456 is involved in the PI3K/Akt signaling pathway due to its unique structure and expression pattern. It is a key gene that is highly expressed in various tissues and cells, including human brain, heart, and cancer cells. The expression pattern of LOC105373456 is consistent with its involvement in the PI3K/Akt signaling pathway.

Drug Discovery

LOC105373456 is a promising candidate for drug discovery due to its unique structure, expression pattern, and function. The PI3K/Akt signaling pathway is a highly validated target for drug development, and LOC105373456 is a unique gene that is involved in this pathway. Therefore, Small molecules that can inhibit the PI3K/Akt signaling pathway may be useful for drug discovery.

Conclusion

LOC105373456 is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a key gene in the PI3K/Akt signaling pathway, which is involved in various cellular processes, including cell survival, angiogenesis, and inflammation. The expression pattern of LOC105373456 is highly consistent with its involvement in this pathway, and small molecules that can inhibit the PI3K/Akt signaling pathway may be useful for drug discovery. Further studies are needed to determine the function of LOC105373456 and its potential as a drug target.

Protein Name: Uncharacterized LOC105373456

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•   protein structure and compound binding;
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•   expression level;
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•   drug resistance;
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