CMKLR1: A Protein Involved in Cellular Signaling and Cellular Processes

Target Name: CMKLR1

NCBI ID: G1240

CMKLR1

CMKLR1: A Protein Involved in Cellular Signaling and Cellular Processes

CMKLR1 (chemokine receptor-like 1) is a protein that is expressed in a variety of tissues throughout the body, including the brain, lungs, heart, kidneys, and intestines. It is a member of the chemokine receptor family, which is a group of transmembrane proteins that play a crucial role in the regulation of cellular signaling.

The primary function of CMKLR1 is to interact with and modulate the activity of several different chemokines, which are a type of protein that is secreted by cells in response to specific stimuli. These chemokines help to regulate the movement and behavior of cells, and play a key role in the immune response, inflammation, and tissue repair.

CMKLR1 is also known as CRL-1, and it is a member of the CRL family of chemokine receptors. This family includes several different proteins, including CRL-2, CRL-3, CRL-4, and CRL-5. These proteins are involved in the regulation of cellular signaling processes that are critical for the survival and proper functioning of cells.

One of the key functions of CMKLR1 is its ability to modulate the activity of chemokines. This is done through a process called phosphorylation, which involves the addition of a phosphate group to a specific amino acid residue on the protein. Phosphorylation is a critical process that helps to regulate the activity and stability of many different proteins, including CMKLR1.

Phosphorylation of CMKLR1 has been shown to play a key role in the regulation of the immune response and inflammation. For example, studies have shown that CMKLR1 is involved in the regulation of T cell activity, which is critical for the immune response to infection and disease. Additionally, CMKLR1 has been shown to play a key role in the regulation of inflammation, and is involved in the development of fibrosis and cancer.

Another function of CMKLR1 is its ability to interact with and modulate the activity of other proteins. This is done through a process called protein-protein interactions, which are interactions between two or more proteins that can affect the activity of one or more of those proteins. CMKLR1 has been shown to play a key role in these interactions, and is involved in the regulation of a wide range of cellular processes.

CMKLR1 is also involved in the regulation of cell signaling processes that are critical for the survival and proper functioning of cells. For example, studies have shown that CMKLR1 is involved in the regulation of cell division, cell growth, and cell survival. Additionally, CMKLR1 has been shown to play a key role in the regulation of cell migration, which is critical for the formation of tissues and organs.

In conclusion, CMKLR1 is a protein that is involved in a wide range of cellular processes that are critical for the survival and proper functioning of cells. Its primary function is to interact with and modulate the activity of several different chemokines, which are a type of protein that is secreted by cells in response to specific stimuli. Additionally, CMKLR1 is involved in the regulation of many different cellular processes, including T cell activity, inflammation, protein-protein interactions, and cell signaling processes. As a drug target or biomarker, CMKLR1 has the potential to be a valuable tool for the study of a wide range of cellular processes.

Protein Name: Chemerin Chemokine-like Receptor 1

Functions: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism

The "CMKLR1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CMKLR1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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