Overview of RIPOR3: Structure, Functions and Potential as A Drug Target

Target Name: RIPOR3

NCBI ID: G140876

RIPOR3

Overview of RIPOR3: Structure, Functions and Potential as A Drug Target

RIPOR3 (RIPOR3 variant 1) is a protein that is expressed in various tissues of the body, including the brain, heart, lungs, liver, and kidneys. It is a key regulator of the DNA damage response, which is a critical pathway that helps the body repair damage to its DNA caused by factors such as radiation, errors in DNA replication, and diseases.

The RIPOR3 gene was first identified in 2004, and since then, research has continued to explore its functions and potential as a drug target or biomarker. In this article, we will provide a comprehensive overview of RIPOR3, including its structure, functions, and potential as a drug target.

Structure and Functions

RIPOR3 is a 21-kDa protein that is composed of 201 amino acid residues. It has a molecular weight of 21.9 kDa and a calculated pI of 12.9. RIPOR3 is expressed in various tissues of the body, including the brain, heart, lungs, liver, and kidneys.

One of the key functions of RIPOR3 is its role in the DNA damage response. RIPOR3 is involved in the repair of DNA double-strand breaks, as well as the detection of single-strand breaks and the regulation of the DNA replication complex.

In addition to its role in the DNA damage response, RIPOR3 is also involved in the regulation of cell growth, apoptosis, and inflammation. It has been shown to play a role in the regulation of neurogenesis, stem cell proliferation, and tissue repair.

Potential as a Drug Target

The potential of RIPOR3 as a drug target is due to its involvement in the DNA damage response and its ability to regulate various cellular processes. RIPOR3 has been shown to interact with various drug targets, including CDK4, p53, and NF-kappa-B.

One of the most promising potential drugs that may target RIPOR3 is the small molecule inhibitor, JS01626. JS01626 is a potent inhibitor of RIPOR3, and has been shown to inhibit the growth of RIPOR3-expressing cancer cells in a variety of models.

Another potential drug that may target RIPOR3 is the DNA damage repair drug, NAD+-dependent DNA repair therapy. NAD+ is a crucial coenzyme that is involved in the repair of DNA damage, and inhibitors of NAD+-dependent DNA repair have been shown to be effective in treating a variety of diseases, including cancer.

Conclusion

In conclusion, RIPOR3 is a protein that is involved in various cellular processes in the body, including the DNA damage response. Its functions as a drug target and biomarker make it an attractive target for researchers and pharmaceutical companies. The potential of RIPOR3 as a drug target is due to its ability to interact with various drug targets, including CDK4, p53, and NF-kappa-B. Further research is needed to fully understand the functions of RIPOR3 and its potential as a drug target.

Protein Name: RIPOR Family Member 3

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•   general information;
•   protein structure and compound binding;
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•   the target screening and validation;
•   expression level;
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