E2F5: A Drug Target / Disease Biomarker (G1875)

Target Name: E2F5

NCBI ID: G1875

E2F5

E2F5: A Drug Target / Disease Biomarker

E2F5, also known as SIRT3, is a non-coding RNA molecule that plays a crucial role in cell processes such as DNA replication, transcription, and apoptosis. It is a key regulator of the DNA damage response and has been implicated in a variety of diseases, including cancer, neurodegenerative diseases, and aging. In this article, we will discuss the research on E2F5 as a drug target and its potential applications in the development of new therapies.

E2F5 is a highly conserved RNA molecule that is found in all cells. It is composed of a unique hairpin-like structure that consists of a 21-amino acid residue, a 2'-ribonucleotide hybrid, and a 3'-end. The E2F5 protein has a critical role in regulating DNA replication and transcription. It interacts with the DNA template and helps to ensure the accuracy and efficiency of the replication process. Additionally, E2F5 is involved in the regulation of apoptosis, which is the natural cell death process that helps to remove damaged or dysfunctional cells.

One of the most significant findings related to E2F5 is its role in the DNA damage response. DNA damage can occur due to various factors, such as exposure to mutagenic agents, radiation, or chemical stress. The DNA damage response is a complex process that involves multiple proteins and RNA molecules working together to repair damaged DNA. E2F5 is a key regulator of this process, as it helps to ensure that the repair machinery is properly assembled and that the repair process is efficient.

E2F5 has also been shown to be involved in a variety of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. These conditions are characterized by the progressive loss of brain cells, which can lead to a range of symptoms such as memory loss, confusion, and difficulty with daily activities. E2F5 has been shown to be involved in the regulation of neurogenesis, which is the process by which new neurons are produced in the brain. Additionally, E2F5 has been shown to play a role in the regulation of neuroinflammation, which is the inflammation that occurs in the brain in response to injury or disease.

E2F5 has also been shown to be involved in aging. As we age, the number of DNA damage events that occur in the cell increases, which can lead to a progressive accumulation of mutations in the DNA. E2F5 has been shown to play a role in the regulation of DNA repair and has been implicated in the aging process.

In addition to its role in cell processes, E2F5 has also been shown to have potential as a drug target. E2F5 has been shown to interact with a variety of protein molecules, including HDACs, which are proteins that can inhibit the activity of histone deacetylases, a type of enzyme that is involved in the regulation of DNA replication and aging. By interacting with HDACs, E2F5 may help to prevent the accumulation of DNA damage that occurs with aging.

E2F5 has also been shown to interact with the protein SIRT6, which is a natural antioxidant that is involved in a variety of cellular processes. SIRT6 has been shown to play a role in the regulation of DNA damage and may help to protect against the accumulation of DNA damage that occurs with aging.

In conclusion, E2F5 is a non-coding RNA molecule that plays a critical role in cell processes such as DNA replication, transcription, and apoptosis. Its role in the regulation of DNA damage response and its potential as a drug target make it an attractive target for the development of new therapies for a variety of diseases, including cancer, neurodegenerative diseases, and aging. Further research is needed to fully understand the role of E2F5 in these processes and to develop effective therapies based on its properties.

Protein Name: E2F Transcription Factor 5

Functions: Transcriptional activator that binds to E2F sites, these sites are present in the promoter of many genes whose products are involved in cell proliferation. May mediate growth factor-initiated signal transduction. It is likely involved in the early responses of resting cells to growth factor stimulation. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis

The "E2F5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about E2F5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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