Target Name: TET3
NCBI ID: G200424
Review Report on TET3 Target / Biomarker Content of Review Report on TET3 Target / Biomarker
TET3
Other Name(s): tet oncogene family member 3 | KIAA0401 | OTTHUMP00000202526 | Probable methylcytosine dioxygenase TET3 | Tet oncogene family member 3 | TET3_HUMAN | Methylcytosine dioxygenase TET3 (isoform 1) | Putative methylcytosine dioxygenase | hCG_40738 | tet methylcytosine dioxygenase 3 | putative methylcytosine dioxygenase | MGC22014 | BEFAHRS | Tet methylcytosine dioxygenase 3, transcript variant 1 | ten-eleven translocation 3 | Methylcytosine dioxygenase TET3 | probable methylcytosine dioxygenase TET3 | TET3 variant 1

Tet3: A Potential Drug Target for Various Diseases

Tet oncogene family member 3 (TET3) is a gene that has been identified as a potential drug target for various diseases, including cancer. Tet oncogene family members are a family of transmembrane proteins that are known for their ability to induce cell proliferation and play a role in the development of cancer. TET3 is a member of the Tet oncogene family and is expressed in various tissues and organs, including brain, heart, and gastrointestinal tract.

The Tet oncogene family is characterized by the presence of a unique transmembrane domain that contains a conserved catalytic core and several unique features. This conserved catalytic core is thought to play a key role in the regulation of cell proliferation and is the site of several known drugs that are currently in use as anti-cancer agents. Additionally, Tet oncogene family members often have a neuropeptide domain that is involved in cell signaling and are thought to play a role in the development of neurodegenerative diseases.

TET3 is a protein that is expressed in various tissues and organs and is involved in the regulation of cell proliferation, differentiation, and survival. It is a member of the Tet oncogene family and is thought to play a role in the development and progression of various diseases, including cancer.

One of the key functions of Tet oncogene family members is their ability to induce cell proliferation. This is thought to be achieved by the regulation of several key signaling pathways, including the Tet signaling pathway. The Tet signaling pathway is a complex signaling pathway that is involved in the regulation of cell proliferation, differentiation, and survival. It is thought to play a key role in the development and progression of cancer and is the target of several drugs that are currently in use as anti-cancer agents.

Tet3 is also involved in the regulation of cell survival and stress responses. It is able to induce cell survival by activating several signaling pathways, including the Tet-INK4a pathway. This pathway is known to be involved in the regulation of cell stress responses and is thought to play a key role in the development and progression of stress-induced diseases. Additionally, Tet3 is involved in the regulation of cell apoptosis, which is the process by which cells die in response to environmental stressors, such as UV radiation or chemical insults.

Tet3 is also involved in the regulation of cell adhesion and migration. It is able to regulate the movement of cells in the body by controlling the activities of several key signaling pathways, including the Tet-MAPK pathway. This pathway is known to be involved in the regulation of cell adhesion and migration and is thought to play a key role in the development and progression of various diseases, including cancer.

In addition to its role in cell proliferation and survival, Tet3 is also involved in the regulation of cell signaling pathways that are important for brain development and function. It is able to regulate the migration of neurons in the brain and is thought to play a key role in the development and progression of neurodegenerative diseases. Additionally, Tet3 is involved in the regulation of cell signaling pathways that are important for eye development and function. It is able to regulate the migration of photoreceptors in the retina and is thought to play a key role in the development and progression of blindness.

Tet3 is also involved in the regulation of cell signaling pathways that are important for wound healing and tissue regeneration. It is able to regulate the production of new cells in response to an wound and is thought to play a key role in the development and progression of wound healing disorders. Additionally, Tet3 is involved in the regulation of cell signaling pathways that are important for cell signaling in the immune system. It is able to regulate the movement of immune cells and is thought to play a key role in the development and progression of

Protein Name: Tet Methylcytosine Dioxygenase 3

Functions: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization (PubMed:31928709). Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation (By similarity). Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes (PubMed:23217707). In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin (By similarity). In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT (PubMed:23353889). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034)

The "TET3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TET3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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