TFEB: A Crucial Regulator of T-cell Development and Function (G7942)

Target Name: TFEB

NCBI ID: G7942

TFEB

TFEB: A Crucial Regulator of T-cell Development and Function

T-cell transcription factor EB (TFEB) is a protein that plays a crucial role in the development and regulation of T-cells, which are a vital part of the immune system. TFEB is a transcription factor that regulates the expression of genes in the T-cells, and it is essential for the proper functioning of T-cells.

TFEB was first identified in the 1990s as a gene that was expressed in the T-cells, and it has since been shown to play a role in the development and regulation of T-cells. TFEB is a transmembrane protein that is expressed in the T-cells. -cells, and it is involved in the regulation of the expression of genes in these cells.

One of the key functions of TFEB is its ability to bind to specific DNA sequences and regulate the expression of genes that are located within these sequences. This is accomplished through the use of a unique domain called the T-cell specific transcription factor (TSTF) domain, which is present in the center of the protein. The TSTF domain is responsible for the binding of TFEB to specific DNA sequences, and it is the site where many of the protein's functional interactions occur.

Another important function of TFEB is its ability to regulate the expression of genes that are involved in the development and differentiation of T-cells. TFEB has been shown to play a role in the regulation of the expression of genes involved in the development of T-cells. cells, such as the PDCD1 gene. This gene is involved in the development of the Plasma Cell, which is a type of T-cell that is responsible for producing antibodies. TFEB has also been shown to play a role in the regulation of the expression of genes involved in the differentiation of T-cells, such as the CD4+T cell differentiation antigen (CD4+TCA) gene.

TFEB is also involved in the regulation of the expression of genes that are involved in the regulation of the immune response. TFEB has been shown to play a role in the regulation of the expression of genes involved in the immune response, such as the NF-kappa-B gene. This gene is involved in the regulation of inflammation and immune responses, and TFEB has been shown to play a role in its regulation.

TFEB is also involved in the regulation of the expression of genes that are involved in the regulation of cell death. TFEB has been shown to play a role in the regulation of cell death, and it has been shown to play a role in the apoptosis ( programmed cell death) of T-cells. This is accomplished through the use of the FAS-associated death-domain (FADD) domain, which is present in the protein and is involved in the regulation of cell death.

TFEB is also involved in the regulation of the expression of genes that are involved in the regulation of DNA repair. TFEB has been shown to play a role in the regulation of DNA repair, and it has been shown to play a role in the repair of DNA damage in T-cells. This is accomplished through the use of the glutathione-S-transferase 2 (GST) domain, which is present in the protein and is involved in the regulation of DNA repair.

TFEB is also involved in the regulation of the expression of genes that are involved in the regulation of cell signaling pathways. TFEB has been shown to play a role in the regulation of cell signaling pathways, and it has been shown to play a role in the regulation of many different signaling pathways. This is accomplished through the use of various domains within the protein, including the TSTF domain, the FADD domain, and the GST domain.

TFEB is also involved in the regulation of the expression of genes that are involved in the regulation of cell

Protein Name: Transcription Factor EB

Functions: Transcription factor that acts as a master regulator of lysosomal biogenesis, autophagy, lysosomal exocytosis, lipid catabolism, energy metabolism and immune response (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:25720963, PubMed:30120233, PubMed:31672913, PubMed:32753672, PubMed:35662396). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF (PubMed:1748288, PubMed:19556463, PubMed:29146937). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFEB phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:21617040, PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:25720963, PubMed:32753672, PubMed:35662396). Upon starvation or lysosomal stress, inhibition of MTOR induces TFEB dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:22576015, PubMed:22343943, PubMed:22692423, PubMed:25720963, PubMed:32753672, PubMed:35662396). Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression, thereby playing a central role in expression of lysosomal genes (PubMed:19556463, PubMed:22692423). Regulates lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of autophagy by promoting expression of genes involved in autophagy (PubMed:21617040, PubMed:22576015, PubMed:23434374, PubMed:27278822). In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer (PubMed:2115126). Plays a role in the signal transduction processes required for normal vascularization of the placenta (By similarity). Involved in the immune response to infection by the bacteria S.aureus, S.typhimurium or S.enterica: infection promotes itaconate production, leading to alkylation, resulting in nuclear localization and transcription factor activity (PubMed:35662396). Itaconate-mediated alkylation activates TFEB-dependent lysosomal biogenesis, facilitating the bacteria clearance during the antibacterial innate immune response (PubMed:35662396)

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