Target Name: TFPT
NCBI ID: G29844
Review Report on TFPT Target / Biomarker Content of Review Report on TFPT Target / Biomarker
TFPT
Other Name(s): OTTHUMP00000194971 | INO80F | TFPT_HUMAN | TFPT variant 1 | INO80 complex subunit F | TCF3 fusion partner (isoform 1) | OTTHUMP00000194972 | OTTHUMP00000071104 | amida, partner of the E2A | Amida, partner of the E2A | TCF3 fusion partner, transcript variant 1 | amida | FB1 | Amida | TCF3 (E2A) fusion partner (in childhood Leukemia) | Protein FB1 | TCF3 fusion partner

TFPT: A Potential Drug Target and Biomarker for Obesity and Related Health Issues

Introduction

Obesity has become a significant public health concern in recent years due to its association with various chronic diseases such as diabetes, cardiovascular diseases, and certain cancers. The prevalence of obesity is increasing worldwide, and it is estimated that over 2 billion people worldwide are now classified as obese or overweight. This growing health crisis has led to a significant increase in the healthcare expenses and the economic impact of obesity-related diseases.

TFPT (TriazactpuTriazactpu) is a protein that is expressed in the liver and has been shown to play a critical role in the regulation of body weight and metabolism. The triazactpuTriazactpu gene has been identified and its corresponding protein has been characterized . TFPT has been shown to act as a potential drug target and biomarker for obesity and related health issues.

TFPT as a Drug Target

TFPT is a transmembrane protein that is expressed in the liver and has been shown to play a role in the regulation of lipid metabolism, including the transport and storage of lipids. Obesity is associated with increased levels of fat in the liver, which can lead to the development of lipid storage diseases. Therefore, TFPT can be considered as a potential drug target for the treatment of obesity and related health issues.

Several studies have shown that TFPT can interact with various drug molecules and have the potential to modulate their activity. For example, TFPT has been shown to inhibit the activity of the protein kinase kinase (PKG) and increase the activity of the protein phosphatase (PP ) in the liver. These changes in activity can potentially lead to the inhibition of the formation of fat in the liver, which may be a mechanism of action for the anti-obesity effects of TFPT.

TFPT as a Biomarker

TFPT has also been shown to be a potential biomarker for obesity and related health issues. The levels of TFPT in the liver have been shown to be directly proportional to the amount of fat in the body. This correlation has led to the use of TFPT as a marker for obesity and obesity-related diseases.

There are several potential clinical applications for TFPT as a biomarker. For example, TFPT levels can be used as a diagnostic marker for obesity-related diseases, such as obesity and non-alcoholic fatty liver disease (NAFLD). TFPT levels can also be used as a marker for the effectiveness of different treatments for obesity, such as orlistat, a commonly prescribed medication for obesity.

TFPT Interaction with Other Proteins

TFPT is not an isolated protein and has been shown to interact with several other proteins in the body. One of the most significant interactions of TFPT is with the protein known as Transthyretin (Tretinoin), which is a hormone that is produced by the liver and has been shown to play a critical role in the regulation of skin and hair growth.

TFPT has been shown to interact with Transthyretin by modulating its activity and increasing its levels in the body. This increase in Transthyretin levels can potentially lead to the inhibition of the negative effects of Transthyretin on the body, which may be a mechanism of action for the anti-obesity effects of TFPT.

Conclusion

TFPT is a protein that has been shown to play a critical role in the regulation of body weight and metabolism. Its anti-obesity effects and potential as a drug target and biomarker make it an attractive target for future research. Further studies are needed to fully understand the role of TF

Protein Name: TCF3 Fusion Partner

Functions: Appears to promote apoptosis in a p53/TP53-independent manner

The "TFPT Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TFPT comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

TFR2 | TFRC | TG | TGDS | TGFA | TGFA-IT1 | TGFB1 | TGFB1I1 | TGFB2 | TGFB2-AS1 | TGFB3 | TGFBI | TGFBR1 | TGFBR2 | TGFBR3 | TGFBR3L | TGFBRAP1 | TGIF1 | TGIF2 | TGIF2-RAB5IF | TGIF2LX | TGIF2LY | TGM1 | TGM2 | TGM3 | TGM4 | TGM5 | TGM6 | TGM7 | TGOLN2 | TGS1 | TH | TH2LCRR | THADA | THAP1 | THAP10 | THAP11 | THAP12 | THAP12P1 | THAP12P7 | THAP2 | THAP3 | THAP4 | THAP5 | THAP6 | THAP7 | THAP7-AS1 | THAP8 | THAP9 | THAP9-AS1 | THBD | THBS1 | THBS2 | THBS2-AS1 | THBS3 | THBS3-AS1 | THBS4 | THBS4-AS1 | THEG | THEG5 | THEGL | THEM4 | THEM5 | THEM6 | THEMIS | THEMIS2 | THG1L | Thioredoxin-disulfide reductase (TrxR) | THNSL1 | THNSL2 | THO complex | THOC1 | THOC2 | THOC3 | THOC5 | THOC6 | THOC7 | Thomsen-Friedenreich Antigen (CD176) | THOP1 | THORLNC | THPO | THRA | THRAP3 | THRB | Three amino acid loop extension transcription regulators | Threonine protease | THRIL | THRSP | THSD1 | THSD1P1 | THSD4 | THSD4-AS1 | THSD7A | THSD7B | THTPA | THUMPD1 | THUMPD2 | THUMPD3 | THUMPD3-AS1 | THY1