The Role of TGFB1I1 in Disease Progression (G7041)

The Role of TGFB1I1 in Disease Progression

TGFB1I1, also known as Transforming Growth Factor Beta 1 Induced Transcript 1, has gained significant attention in recent years as a potential drug target and biomarker for various diseases. This article will explore the role of TGFB1I1 in disease progression and its potential in developing targeted therapies.

Understanding TGFB1I1

TGFB1I1 is a gene that encodes a protein which plays a crucial role in the regulation of cell proliferation, differentiation, and apoptosis. It is primarily associated with the transforming growth factor-beta (TGF-β) signaling pathway, which is involved in numerous physiological processes, including embryonic development, tissue repair, and immune response.

TGFB1I1 as a Key Player in Cancer

One of the most notable roles of TGFB1I1 is its involvement in cancer progression. Studies have shown that TGFB1I1 is overexpressed in various cancer types, including breast, lung, and colorectal cancer. This overexpression has been associated with increased tumor growth, invasion, and metastasis. It is believed that TGFB1I1 promotes cancer progression by enhancing TGF-β signaling, which in turn promotes epithelial-mesenchymal transition (EMT), a process crucial for the migration and invasion of cancer cells.

Targeting TGFB1I1 for Cancer Therapy

Given the significant role of TGFB1I1 in cancer progression, it has emerged as a promising target for novel cancer therapies. Researchers are actively exploring different approaches to inhibit TGFB1I1 and its downstream signaling pathways. One approach involves the development of small molecules or antibodies that specifically target TGFB1I1, blocking its interaction with critical proteins involved in the TGF-β signaling pathway. This targeted inhibition could inhibit tumor growth and metastasis.

Another strategy involves gene therapy techniques to silence or reduce the expression of TGFB1I1. By using RNA interference or CRISPR/Cas9 technology, researchers aim to selectively eliminate or downregulate TGFB1I1 expression within tumor cells, impairing their ability to progress and invade surrounding tissues.

TGFB1I1 as a Potential Biomarker

Apart from its potential as a therapeutic target, TGFB1I1 has also shown promise as a biomarker for disease prognosis and monitoring. In several studies, elevated levels of TGFB1I1 have been correlated with poor prognosis and disease progression in various cancers. This suggests that measuring TGFB1I1 expression levels could provide valuable information about disease severity and patient outcomes.

Moreover, TGFB1I1 expression levels might help predict response to certain therapies. For instance, in colorectal cancer, high levels of TGFB1I1 have been associated with resistance to chemotherapy and radiation therapy. By assessing TGFB1I1 expression before treatment initiation, clinicians could tailor therapy regimens to maximize effectiveness and minimize adverse effects.

Conclusion

TGFB1I1, as a critical player in the TGF-β signaling pathway, has emerged as an important drug target and biomarker in disease progression. Its role in cancer progression, particularly in promoting tumor growth and metastasis, has motivated researchers to develop targeted therapies aimed at inhibiting TGFB1I1. Additionally, the measurement of TGFB1I1 expression levels could hold significant value in predicting disease outcomes and guiding treatment decisions. Further research and clinical studies are necessary to fully understand the potential of TGFB1I1 as a therapeutic target and biomarker, paving the way for improved disease management strategies.

Protein Name: Transforming Growth Factor Beta 1 Induced Transcript 1

Functions: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity

The "TGFB1I1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TGFB1I1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

TGFB2 | TGFB2-AS1 | TGFB3 | TGFBI | TGFBR1 | TGFBR2 | TGFBR3 | TGFBR3L | TGFBRAP1 | TGIF1 | TGIF2 | TGIF2-RAB5IF | TGIF2LX | TGIF2LY | TGM1 | TGM2 | TGM3 | TGM4 | TGM5 | TGM6 | TGM7 | TGOLN2 | TGS1 | TH | TH2LCRR | THADA | THAP1 | THAP10 | THAP11 | THAP12 | THAP12P1 | THAP12P7 | THAP2 | THAP3 | THAP4 | THAP5 | THAP6 | THAP7 | THAP7-AS1 | THAP8 | THAP9 | THAP9-AS1 | THBD | THBS1 | THBS2 | THBS2-AS1 | THBS3 | THBS3-AS1 | THBS4 | THBS4-AS1 | THEG | THEG5 | THEGL | THEM4 | THEM5 | THEM6 | THEMIS | THEMIS2 | THG1L | Thioredoxin-disulfide reductase (TrxR) | THNSL1 | THNSL2 | THO complex | THOC1 | THOC2 | THOC3 | THOC5 | THOC6 | THOC7 | Thomsen-Friedenreich Antigen (CD176) | THOP1 | THORLNC | THPO | THRA | THRAP3 | THRB | Three amino acid loop extension transcription regulators | Threonine protease | THRIL | THRSP | THSD1 | THSD1P1 | THSD4 | THSD4-AS1 | THSD7A | THSD7B | THTPA | THUMPD1 | THUMPD2 | THUMPD3 | THUMPD3-AS1 | THY1 | Thymidine Kinase | THYN1 | Thyroid hormone receptor | Thyrostimulin | Thyrotropin | TIA1 | TIAF1 | TIAL1