TFAP2E: A Potential Drug Target and Biomarker for Adaptor-related Protein Complex 2 (ERC)

Target Name: TFAP2E

NCBI ID: G339488

TFAP2E

TFAP2E: A Potential Drug Target and Biomarker for Adaptor-related Protein Complex 2 (ERC)

Protein-protein interactions (PPIs) play a crucial role in cellular signaling and are often associated with various diseases. One of the well-established PPI systems is the adaptor-related protein complex 2 (ERC), which is composed of various proteins that help recruit adaptor proteins to their respective targets. The epsilon subunit (TFAP2E) of ERC is one of the key components, and its dysfunction has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

TFAP2E is a 21-kDa protein that contains a unique N-terminal domain, known as the N-terminal hypervariable region (HVR), which is involved in the formation and stability of the protein. The HVR is a conserved region that is commonly found in proteins that play a critical role in various cellular processes, including cell signaling, protein-protein interactions, and subcellular localization.

TFAP2E functions as an adaptor protein, which means it can form multiple interactions with various protein partners, including tyrosine kinases, leading to the recruitment of adaptor proteins to their targets. The unique feature of TFAP2E is its ability to form a stable interaction with the protein kinase Bcr, which is critical for the recruitment of Bcr to its target, leading to the formation of the Bcr-Abl fusion protein. This interaction between TFAP2E and Bcr is a crucial step in the Bcr signaling pathway, which is involved in various cellular processes, including cell growth, survival, and angiogenesis.

TFAP2E has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, TFAP2E has been shown to be overexpressed in various cancer types, including breast, ovarian, and colorectal cancers. Additionally, TFAP2E has been linked to various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. The dysfunction of TFAP2E has been implicated in the development of these diseases, and targeting TFAP2E may provide new insights into the pathogenesis of these diseases.

TFAP2E has also been shown to be involved in various signaling pathways, including the PI3K/AKT signaling pathway. This pathway is involved in the regulation of cellular signaling and has been implicated in various cellular processes, including cell survival, angiogenesis, and inflammation. TFAP2E has been shown to be involved in the regulation of the PI3K/AKT signaling pathway, which may provide new targets for the development of therapeutic agents that target this pathway.

In addition to its role in cellular signaling, TFAP2E has also been shown to play a critical role in the regulation of protein-protein interactions. TFAP2E has been shown to form multiple interactions with various proteins, including Bcr, leading to the recruitment of adaptor proteins to their targets. This interaction between TFAP2E and adaptor proteins is critical for the regulation of protein-protein interactions and has implications for the development of new therapeutic agents.

TFAP2E is also a potential biomarker for various diseases. The dysfunction of TFAP2E has been implicated in the development of various diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, TFAP2E has been shown to be overexpressed in various cancer types, including breast, ovarian, and colorectal cancers. Additionally, TFAP2E has been linked to various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. The dysfunction of TFAP2E may be a potential biomarker for the development

Protein Name: Transcription Factor AP-2 Epsilon

Functions: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity)

The "TFAP2E Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TFAP2E comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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