TFAM: A Potential Drug Target and Biomarker for Mitochondrial Function

Target Name: TFAM

NCBI ID: G7019

TFAM

TFAM: A Potential Drug Target and Biomarker for Mitochondrial Function

Mitochondria are dynamic organelles that play a crucial role in powering cells throughout the entire organism. They are the primary powerhouses of the cell, producing the majority of the energy that the cell needs to function. Subunits of the mitochondria, called mitochondrial fission fragments (MFFs), have been implicated in a wide range of cellular processes, including apoptosis, autophagy, and cellular signaling. TFAM, or transcription factor A, mitochondrial (isoform 1), is one of these MFFs that has received increasing attention due to its unique biology and potential role in disease.

In this article, we will explore the biology of TFAM and its potential as a drug target or biomarker. We will discuss the current understanding of TFAM's role in cellular processes, as well as its potential therapeutic applications.

Biography of TFAM

TFAM is a 21-kDa protein that is found in the mitochondria. It is a member of the A subfamily of the TAF (transcription factor A) family, which includes other well-known proteins such as p53 and p21. TFAM was identified as a potential drug target due to its unique biology and its ability to modulate cellular processes in a variety of organisms, including humans.

Mitochondrial Function and TFAM

Mitochondria are organelles that are responsible for generating the majority of the energy for the cell. They are complex organelles that are involved in a wide range of cellular processes, including metabolism, autophagy, and signaling. TFAM is a key component of the mitochondria, and its function is crucial for the overall health and function of the organelle.

TFAM plays a vital role in the regulation of mitochondrial dynamics and metabolism. It is involved in the assembly and disassembly of mitochondrial fission fragments, which are small subunits of the mitochondria that are involved in a variety of cellular processes. TFAM also regulates the activity of other cellular processes, including metabolism, stress response, and autophagy.

TFAM and Disease

The potential therapeutic applications of TFAM are vast, and its potential as a drug target are significant. Several studies have suggested that TFAM may be involved in a wide range of diseases, including cancer, neurodegenerative diseases, and metabolic disorders.

In cancer, TFAM has been shown to be involved in the regulation of cell proliferation and apoptosis. TFAM has been shown to play a critical role in the regulation of the apoptosis pathway, which is a critical mechanism that helps cells eliminate themselves when they are no longer needed.

In neurodegenerative diseases, TFAM has been shown to be involved in the regulation of the stress response and autophagy. TFAM has been shown to play a critical role in the regulation of the stress response, which is a critical mechanism that helps cells adapt to environmental stressors. It has also been shown to play a critical role in the regulation of autophagy, which is a process that helps cells break down damaged or unnecessary cellular components.

In metabolic disorders, TFAM has been shown to be involved in the regulation of energy metabolism. TFAM has been shown to play a critical role in the regulation of glucose metabolism, which is a critical source of energy for the cell.

TFAM as a Drug Target

TFAM has the potential to be a drug target due to its unique biology and its ability to modulate cellular processes in a variety of organisms. Several studies have suggested that TFAM may be a promising drug target for a variety of diseases, including cancer, neurodegenerative diseases, and metabolic disorders.

In cancer, TFAM has been shown to be involved in the regulation of cell

Protein Name: Transcription Factor A, Mitochondrial

Functions: Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation (PubMed:29445193, PubMed:32183942). Component of the mitochondrial transcription initiation complex, composed at least of TFB2M, TFAM and POLRMT that is required for basal transcription of mitochondrial DNA (PubMed:29149603). In this complex, TFAM recruits POLRMT to a specific promoter whereas TFB2M induces structural changes in POLRMT to enable promoter opening and trapping of the DNA non-template strand (PubMed:20410300). Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase (PubMed:22037172). Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites (PubMed:22037172). Is able to unwind DNA (PubMed:22037172). Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes (PubMed:1737790). Required for maintenance of normal levels of mitochondrial DNA (PubMed:22841477, PubMed:19304746). May play a role in organizing and compacting mitochondrial DNA (PubMed:22037171)

The "TFAM Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TFAM comprehensively, including but not limited to:
•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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