FOXK1: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker

Target Name: FOXK1

NCBI ID: G221937

FOXK1

FOXK1: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker

FOXK1 (Foxk1) is a non-coding RNA molecule that plays a crucial role in the regulation of cellular processes. It is a key regulator of cell proliferation, differentiation, and survival.FOXK1 has been identified as a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

During this article, we will discuss the biology of FOXK1, its functions in cellular processes, its potential as a drug target, and its role as a biomarker.

Biography of FOXK1

FOXK1 is a non-coding RNA molecule that is expressed in a variety of tissues, including muscle, liver, brain, and placenta. It is composed of 219 amino acid residues and has a molecular weight of 24.9 kDa. FOXK1 is regulated by various factors , including DNA replication, cell cycle progression, and apoptosis.

FOXK1 functions as a negative regulator of the G1/S transition. It inhibits the G1-to-S transition by binding to the G1-specific protein, p21. FOXK1 has been shown to play a role in the regulation of cell cycle progression by preventing the G1-to-S transition and promoting the G0-to-G1 transition.

FOXK1 is also involved in the regulation of apoptosis. It has been shown to promote apoptosis by activating various stress-responsive pathways, including the JNK pathway. FOXK1 has also been shown to play a role in the regulation of cellular processes that are critical for cell survival, such as cell migration and the regulation of ion channels.

Potential drug targets

FOXK1 has been identified as a potential drug target due to its involvement in various cellular processes that are critical for human health.FOXK1 has been shown to play a role in the regulation of cancer cell growth, and it has been shown to be involved in the development of various types of cancer, including breast, ovarian, and prostate cancer.

FOXK1 has also been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. FOXK1 has also been shown to play a role in the regulation of the production of neurotransmitters, which are critical for the functioning of neurons, and it has been shown to contribute to the development of neurodegenerative diseases.

FOXK1 has also been shown to be involved in the regulation of autoimmune disorders.FOXK1 has been shown to play a role in the regulation of the development and function of immune cells, and it has been shown to contribute to the development of autoimmune disorders.

FOXK1 as a biomarker

FOXK1 has been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. FOXK1 has been shown to be expressed in a variety of tissues and has been shown to play a role in the regulation of various cellular processes. that are critical for human health.

FOXK1 has also been shown to be involved in the regulation of cancer cell growth, and it has been shown to contribute to the development and progression of various types of cancer.FOXK1 has also been shown to be involved in the regulation of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease.FOXK1 has been shown to play a role in the regulation of the production of neurotransmitters, which are critical for the functioning of neurotransmitters

Protein Name: Forkhead Box K1

Functions: Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164)

The "FOXK1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about FOXK1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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