LRCH1: A Protein Involved in Pain Perception and Neuroinflammation

Target Name: LRCH1

NCBI ID: G23143

LRCH1

Other Name(s): KIAA1016 | Leucine-rich repeat and calponin homology domain-containing protein 1 isoform 2 | Neuronal protein 81 | CHDC1 | leucine rich repeats and calponin homology domain containing 1 | Calponin homology domain-containing protein 1 | Leucine-rich repeat and calponin homology domain-containing protein 1 isoform 1 | LRCH1 variant 2 | leucine-rich repeats and calponin homology (CH) domain containing 1 | LRCH1 variant 1 | Calponin homology (CH) domain containing 1 | Leucine-rich repeat and calponin homology domain-containing protein 1 | Leucine rich repeats and calponin homology domain containing 1, transcript variant 2 | LRCH1_HUMAN | Leucine-rich repeats and calponin homology (CH) domain containing 1 | NP81 | Leucine rich repeats and calponin homology domain containing 1, transcript variant 1 | neuronal protein 81

LRCH1: A Protein Involved in Pain Perception and Neuroinflammation

LRCH1 (KiAA1016) is a protein that is expressed in various tissues of the body, including the brain. It is a member of the Kallikrein-related serine proteases (KASP) family and is involved in the regulation of pain, inflammation, and fibrosis. KASPases are known for their ability to generate structurally stable peptides from short amino acid sequences, which can then participate in a variety of cellular signaling pathways.

LRCH1 is a 194 amino acid protein that is expressed in the brain and other tissues. It is characterized by a N-terminal catalytic domain and a C-terminal region that is involved in its interactions with other proteins. The catalytic domain is composed of a unique farnesylated cysteine 鈥嬧?媟esidue, which is known as a "EGF-binding site" (EGF-binding site). This site is thought to play a role in the regulation of cell growth and differentiation, and is a potential target for small molecules that can modulate pain perception.

LRCH1 is involved in a number of cellular signaling pathways, including the regulation of pain perception and neuroinflammation. It is well established that pain is a complex subjective experience that is influenced by the interplay of various physiological and psychological factors. Recent studies have shown that LRCH1 is involved in the regulation of pain perception, with mutations in the LRCH1 gene being associated with increased pain sensitivity in animal models of pain.

In addition to its role in pain perception, LRCH1 is also involved in the regulation of neuroinflammation. Neuroinflammation is a complex inflammatory response that occurs in the brain and is thought to play a role in the development of a variety of neurological disorders, including Alzheimer's disease and other forms of dementia. LRCH1 has been shown to be involved in the regulation of neuroinflammation by participating in multiple signaling pathways, including TGF-β, NF-kappa-B, and other intracellular signaling pathways.

LRCH1 is also involved in the regulation of cell survival and proliferation. It has been shown to play a role in the regulation of cell cycle progression, and is thought to be involved in the regulation of cell apoptosis. This is important for understanding the mechanisms of cancer, as changes in cell apoptosis have been implicated in the development of cancer.

In conclusion, LRCH1 is a protein that is involved in a number of cellular signaling pathways, including the regulation of pain perception, neuroinflammation, cell survival and proliferation. Its role in these processes makes it an attractive target for small molecules that can modulate pain perception and other physiological processes. Further research is needed to fully understand the mechanisms of LRCH1 and its potential as a drug or biomarker.

Protein Name: Leucine Rich Repeats And Calponin Homology Domain Containing 1

Functions: Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration

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