LRP2: A Multi-Functional Protein in Various Tissues and Potential Drug Target

Target Name: LRP2

NCBI ID: G4036

LRP2

LRP2: A Multi-Functional Protein in Various Tissues and Potential Drug Target

Glycoprotein 330 (LRP2) is a protein that is expressed in various tissues throughout the body, including the liver, pancreas, and blood cells. It is a member of the glycoprotein family, which is a group of proteins that are characterized by their ability to form inclusion complexes with other proteins. LRP2 is a 21-kDa protein that consists of 158 amino acid residues.

The LRP2 protein is involved in various physiological processes in the body, including cell signaling, inflammation, and the regulation of immune responses. It is also a potential drug target and has been identified as a potential biomarker for various diseases, including diabetes, cancer, and neurodegenerative disorders.

One of the key functions of LRP2 is its role in cell signaling. LRP2 is a negative regulator of the TGF-β signaling pathway, which is involved in the regulation of cell growth, differentiation, and inflammation. TGF-β signaling is a critical pathway that regulates the development and maintenance of tissues, and it is implicated in a wide range of diseases, including cancer, neurodegenerative disorders, and diabetes.

LRP2 plays a negative role in the TGF-β pathway by regulating the activity of the transcription factor, Smad. Smad is a key regulator of TGF-β signaling, and it is involved in the regulation of cell growth, differentiation, and survival. LRP2 helps to prevent the activity of Smad, which leads to the inhibition of TGF-β signaling.

Another function of LRP2 is its role in inflammation. LRP2 has been shown to be involved in the regulation of immune responses and the regulation of pro-inflammatory responses. LRP2 is a potential drug target for diseases that are characterized by inflammation, such as cancer and neurodegenerative disorders.

LRP2 is also involved in the regulation of energy metabolism. LRP2 is a component of the mitochondrial protein complex, which is responsible for the production of energy in the form of ATP. LRP2 is also involved in the regulation of the import of proteins into the mitochondria, which is important for the regulation of energy metabolism.

In conclusion, LRP2 is a protein that is involved in a wide range of physiological processes in the body. It is a potential drug target and has been identified as a potential biomarker for various diseases. Further research is needed to fully understand the role of LRP2 in cell signaling, inflammation, and energy metabolism.

Protein Name: LDL Receptor Related Protein 2

Functions: Multiligand endocytic receptor (By similarity). Acts together with CUBN to mediate endocytosis of high-density lipoproteins (By similarity). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (By similarity). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (By similarity). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (By similarity). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (By similarity). Mediates renal uptake of metallothionein-bound heavy metals (PubMed:15126248). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (By similarity). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (By similarity). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (By similarity). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (By similarity). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (By similarity). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (By similarity). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (By similarity). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (By similarity). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (By similarity). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (By similarity). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensis 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (By similarity). Required for normal hearing, possibly through interaction with estrogen in the inner ear (By similarity)

The "LRP2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LRP2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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