LRIT3: A Protein Involved in The Immune Response (G345193)

Target Name: LRIT3

NCBI ID: G345193

LRIT3

Other Name(s): leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 | CSNB1F | FIGLER4 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 | fibronectin type III, immunoglobulin and leucine rich repeat domains 4 | LRIT3_HUMAN | leucine rich repeat, Ig-like and transmembrane domains 3 | Fibronectin type III, immunoglobulin and leucine rich repeat domains 4 | Leucine rich repeat, Ig-like and transmembrane domains 3 | Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3 precursor

LRIT3: A Protein Involved in The Immune Response

LrIT3, also known as immunoglobulin-like and transmembrane domains 3, is a gene that encodes a protein with significant functions in the immune system. The protein encoded by LrIT3 is composed of three domains: leucine-rich repeat, immunoglobulin-like, and transmembrane domains. LrIT3 plays a crucial role in the development and maintenance of the immune response against various pathogens and infections.

The Leucine-Rich Repeat Domain

The leucine-rich repeat (LRR) domain is a common structural feature in proteins that is characterized by the repeated amino acid sequence Leucine-Leucine-Leucine (LLL). LRRs are often involved in protein-protein interactions and play a crucial role in the regulation of protein structure and function. In the case of LrIT3, the LRR domain is responsible for the interaction between the protein and other proteins, as well as its role in the regulation of cellular processes such as cell signaling and inflammation.

The Immunoglobulin-Like Domain

The immunoglobulin-like (Ig-like) domain is a structural protein that is commonly found in many proteins, including antibodies, complement proteins, and signaling proteins. The Ig-like domain is characterized by the presence of a variable region and a constant region . The variable region of the Ig-like domain is responsible for the production of antibodies, while the constant region provides structural stability and participates in several cellular processes.

The Transmembrane Domain

The transmembrane (TM) domain is a structural protein that is responsible for the interaction between the protein and the cell membrane. The TM domain is characterized by the presence of a transmembrane region and an intracellular region. The transmembrane region is responsible for the formation of an ion channel that allows the protein to interact with ligands and other proteins outside the membrane, while the intracellular region is involved in the regulation of cellular processes such as cell signaling and protein degradation.

The Function of LrIT3

The function of LrIT3 is tightly linked to the regulation of the immune response. LrIT3 is involved in the development and maintenance of memory T cells, which are a critical component of the immune system against pathogens and infections. LrIT3 is also involved in the regulation of cellular processes such as cell signaling, DNA replication, and protein degradation.

Drug Targeting and Biomarkers

Drug targeting and biomarker development are important tools for the discovery of new therapeutic compounds. The LrIT3 protein is a potential drug target due to its involvement in the immune response and its unique structure. The LrIT3 protein can be used as a biomarker for the assessment of therapeutic compounds and for the development of new diagnostic tools.

Conclusion

The LrIT3 protein is a unique and highly functional protein that is involved in the regulation of the immune response. The Leucine-Rich Repeat, Ig-like, and transmembrane domains of LrIT3 provide a framework structural that allows it to interact with other proteins and participate in a wide range of cellular processes. The potential drug targeting and biomarker development of LrIT3 make it an attractive target for new therapeutic compounds and diagnostic tools.

Protein Name: Leucine Rich Repeat, Ig-like And Transmembrane Domains 3

Functions: Plays a role in the synapse formation and synaptic transmission between cone photoreceptor cells and retinal bipolar cells (By similarity). Required for normal transmission of a light-evoked stimulus from the cone photoreceptor cells to the ON-bipolar cells and ON-ganglion cells in the inner retina (PubMed:28334377). Required in retinal ON-bipolar cells for normal localization of the cation channel TRPM1 at dendrite tips (By similarity). Seems to play a specific role in synaptic contacts made by ON-bipolar cells with cone photoreceptor pedicles (By similarity). May also have a role in cone synapse formation (By similarity). Might facilitate FGFR1 exit from the endoplasmic reticulum to the Golgi (PubMed:22673519). Could be a regulator of the FGFRs (PubMed:22673519)

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