LRRC55: A Potential Drug Target and Biomarker for Diseases (G219527)

Target Name: LRRC55

NCBI ID: G219527

LRRC55

LRRC55: A Potential Drug Target and Biomarker for Diseases

The protein LRRC55 is a unique nuclear protein that is expressed in various tissues and cell types in the human body. It is characterized by a unique repeat sequence that is present in approximately 55% of human protein sequences. This protein has been identified as a potential drug target and may also serve as a biomarker for various diseases.

The LRRC55 protein

The LRRC55 protein is a 21-kDa protein that is expressed in various tissues, including muscle, heart, brain, and stem cells. It is characterized by a single transmembrane domain and a unique N-terminal region that contains a repeat sequence of leucine residues. This repeat sequence is composed of the amino acids GGGAA, which is repeated in a specific order to form the characteristic LRRC55 repeat.

The LRRC55 repeat

The LRRC55 repeat is the most distinctive feature of the LRRC55 protein. It is a 19-amino acid repeat that is repeated in approximately 55% of human protein sequences. The LRRC55 repeat is composed of the amino acids GGGAA, which is repeated in a specific order to form a loop of three amino acids. This repeat sequence is located at the N-terminus of the protein and is responsible for the unique physical and chemical properties of the LRRC55 protein.

The potential drug target

The LRRC55 repeat has been identified as a potential drug target due to its unique structure and the various functions that it is involved in. One of the main reasons for its potential as a drug target is its involvement in various signaling pathways, including the TGF-β pathway and the Wnt pathway. These signaling pathways are involved in various cellular processes that are important for the development and maintenance of tissues and organs, including muscle and heart cells.

In addition, the LRRC55 repeat has also been shown to be involved in the regulation of various cellular processes, including cell adhesion, migration, and invasion. This suggests that it may also be a useful biomarker for the diagnosis and treatment of various diseases.

The biomarker potential

The LRRC55 repeat has also been shown to be involved in the regulation of various cellular processes, including cell adhesion, migration, and invasion. This suggests that it may also be a useful biomarker for the diagnosis and treatment of various diseases.

For example, studies have shown that LRRC55 is involved in the regulation of cell adhesion and that it plays a role in the development and maintenance of tight junctions, which are important for the regulation of ion and solute transport in tissues. In addition, LRRC55 has also been shown to be involved in the regulation of cell migration and invasion, which are important for the development and maintenance of tissues and organs.

Conclusion

The LRRC55 protein is a unique and highly conserved protein that is expressed in various tissues and cell types in the human body. It is characterized by a single transmembrane domain and a unique N-terminus region that contains a repeat sequence of leucine residues. The LRRC55 repeat has been identified as a potential drug target and may also serve as a biomarker for various diseases. Further research is needed to fully understand the role of the LRRC55 protein in various cellular processes and to develop effective treatments for the diagnosis and treatment of diseases associated with its dysfunction.

Protein Name: Leucine Rich Repeat Containing 55

Functions: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
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