LRRC4B: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker

Target Name: LRRC4B

NCBI ID: G94030

LRRC4B

LRRC4B: A Non-Coding RNA Molecule as A Potential Drug Target and Biomarker

LRRC4B (long non-coding RNA-coding gene, also known as HSM) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker. It is a key regulator of hematopoietic stem cell (HSC) self-renewal and has been shown to play a role in the development and maintenance of various diseases, including cancer.

The LRRC4B gene was identified through a combination of computational and experimental approaches, including RNA sequencing and gene expression analysis. The results of these studies revealed that LRRC4B is a highly expressed gene in a variety of tissues and cells, including blood cells, tissues, and organs. It is also highly co-expressed with several key genes involved in cell growth, differentiation, and survival, including PDGFRA, ID4, and NF1.

In addition to its expression, LRRC4B has also been shown to play a role in the regulation of DNA replication and metabolism. It is a component of the RNA polymerase II complex, which is responsible for copying DNA in the cell. LRRC4B has been shown to play a role in the regulation of DNA replication by binding to the enzyme responsible for DNA synthesis, called DNA polymerase II. This interaction between LRRC4B and DNA polymerase II suggests that LRRC4B may be involved in the regulation of DNA replication, which could have implications for the development of cancer.

LRRC4B has also been shown to be involved in the regulation of cell adhesion and migration. It is a component of the tight junction, a structure that helps to maintain the integrity of cell boundaries and keep cells in place. LRRC4B has been shown to play a role in the regulation of tight junction formation by binding to the protein zeb2, which is involved in the formation of tight junctions. This interaction between LRRC4B and zeb2 suggests that LRRC4B may be involved in the regulation of cell adhesion and migration, which could have implications for the development of invasive and metastatic diseases.

In addition to its role in cell growth and differentiation, LRRC4B has also been shown to be involved in the regulation of inflammation and immune response. It is a component of the immune response by T cells, which are responsible for recognizing and responding to foreign substances in the body. LRRC4B has been shown to play a role in the regulation of T cell development and function by binding to the protein PDGF-RF1, which is involved in the regulation of T cell proliferation and survival. This interaction between LRRC4B and PDGF-RF1 suggests that LRRC4B may be involved in the regulation of T cell inflammation and immune response, which could have implications for the development of autoimmune diseases.

LRRC4B has also been shown to be involved in the regulation of cell survival and longevity. It is a component of the p53 pathway, which is responsible for regulating cell growth and apoptosis. LRRC4B has been shown to play a role in the regulation of p53 activity by binding to the protein p53, which is involved in the regulation of DNA replication and apoptosis. This interaction between LRRC4B and p53 suggests that LRRC4B may be involved in the regulation of cell survival and longevity, which could have implications for the development of diseases associated with cellular dysfunction, such as cancer.

In conclusion, LRRC4B is a non-coding RNA molecule that has been shown to play a role in the regulation of various cellular processes, including cell growth, differentiation, inflammation, and immune response. Its involvement in these processes makes it a potential drug target and biomarker for a variety of diseases. Further research is needed to fully understand the role of LRRC4B in these processes and to develop effective therapies based on its properties.

Protein Name: Leucine Rich Repeat Containing 4B

Functions: Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity)

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