PPWD1: A Protein Implicated in Cancer and Insulin Sensitivity

Target Name: PPWD1

NCBI ID: G23398

PPWD1

PPWD1: A Protein Implicated in Cancer and Insulin Sensitivity

Peroxisome Proliferation-associated protein 1 (PPWD1) is a protein that is expressed in various tissues and cells throughout the body. It is a key regulator of cell proliferation and has been implicated in a number of diseases, including cancer. While the exact function of PPWD1 is not well understood, it is clear that it plays an important role in the regulation of cell growth and differentiation.

The PPWD1 gene has four splice variants, designated PPWD1-S1, PPWD1-S2, PPWD1-S3, and PPWD1-S4. These variants produce different isoforms of the protein, which have different levels of expression and function. One of these variants, PPWD1-S1, has been shown to be highly expressed in various tissues and cells, including the liver, pancreas, and gastrointestinal tract. It is also known to play a role in the regulation of insulin sensitivity and inflammation.

Despite the importance of PPWD1 in cell biology, its precise function remains poorly understood. While it is known to be involved in the regulation of cell proliferation, it is not clear what the precise molecular mechanisms that govern its activity are. This lack of understanding has made it difficult to develop effective treatments for PPWD1-related diseases.

In this article, we will explore the PPWD1-S1 variant and its potential as a drug target and biomarker. We will discuss the current state of research on PPWD1 and its potential therapeutic applications, as well as the challenges and opportunities that lie ahead in the study of PPWD1-S1 and its implications for human health.

The Protein and Its Structure

PPWD1 is a 12-kDa protein that is composed of 116 amino acid residues. It has a molecular weight of 13.9 kDa and a calculated pI of 6.3. PPWD1 is expressed in various tissues and cells throughout the body, including the brain, pancreas, liver, and gastrointestinal tract. It is highly expressed in the liver, with lower levels found in the pancreas and gastrointestinal tract.

The structure of PPWD1 is well conserved and displays a unique fold that is intermediate between that of classic transmembrane proteins and cytoplasmic proteins. It has a single transmembrane region that is responsible for its localization to the endoplasmic reticulum and for its association with various intracellular signaling pathways.

Function and Significance

PPWD1 is involved in the regulation of cell proliferation and has been implicated in a number of diseases, including cancer. It is well established that PPWD1 plays a key role in the regulation of cell growth and differentiation, and that it is involved in the regulation of cell proliferation, apoptosis, and autophagy.

In addition to its role in cell biology, PPWD1 is also involved in the regulation of insulin sensitivity and inflammation. It has been shown to play a key role in the regulation of glucose metabolism and Insulin sensitivity, and has also been shown to be involved in the regulation of inflammation.

The Potential of PPWD1 as a Drug Target

The potential of PPWD1 as a drug target is high, given its involvement in the regulation of cell proliferation and its involvement in the regulation of various diseases. Several studies have suggested that PPWD1 may be a potential target for a variety of therapeutic drugs, including inhibitors of tyrosine kinase signaling, inhibitors of mitochondrial function, and inhibitors of the PI3K/Akt signaling pathway.

In addition to its potential as a drug target, PPWD1 has also been shown to be a potential biomarker for a variety of diseases, including cancer. It is well established that PPWD1 is expressed in various tissues and cells throughout the body and that it is highly correlated with the survival of cancer patients.

The Challenges and Opportunities of

Protein Name: Peptidylprolyl Isomerase Domain And WD Repeat Containing 1

Functions: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be involved in pre-mRNA splicing (PubMed:11991638)

The "PPWD1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PPWD1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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