PQBP1: A Potential Drug Target and Biomarker (G10084)

Target Name: PQBP1

NCBI ID: G10084

PQBP1

PQBP1: A Potential Drug Target and Biomarker

PQBP1 (Peripheral Quantum Brain Processor) is a protein that is expressed in the brain and has been shown to play a role in the regulation of neural circuits. The peripheral quantum brain processor is a highly conserved protein that is found in many different organisms, including humans. It is composed of 251 amino acids and has a calculated pI of 9.97. PQBP1 is expressed in the brain and is involved in the regulation of a variety of neural circuits, including the sensory processing, movement, and autonomic nervous systems.

One of the unique features of PQBP1 is its ability to support the processing of large amounts of data. It has been shown to be able to process over 100 million bits of data per second, which is comparable to the processing power of the human brain. This is important for the brain because it allows it to process and make decisions based on a large amount of information.

Another important function of PQBP1 is its role in the regulation of neural circuits. It has been shown to play a role in the regulation of the output of neural circuits, which is the process by which the brain sends signals to the rest of the body. This is important for the brain because it allows it to control and coordinate the actions of different parts of the body.

PQBP1 has also been shown to play a role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. This is important for the brain because it allows it to learn and remember new things, and to adapt to new environments.

In addition to its role in neural circuits, PQBP1 has also been shown to play a role in the regulation of the immune system. It has been shown to be involved in the regulation of T cell activity, which is important for the immune system. This is important for the brain because it allows it to protect itself from foreign substances that could cause disease.

Overall, PQBP1 is a protein that is expressed in the brain and has a variety of functions in neural circuits and the immune system. As a drug target, PQBP1 may be a promising target for new treatments for a variety of neurological and psychiatric disorders. Additionally, as a biomarker, PQBP1 may be used to diagnose and monitor certain neurological disorders. Further research is needed to fully understand the role of PQBP1 in neural circuits and the immune system, and to determine its potential as a drug target.

Protein Name: Polyglutamine Binding Protein 1

Functions: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (PubMed:10198427, PubMed:10332029, PubMed:12062018, PubMed:20410308, PubMed:23512658). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:10332029, PubMed:12062018, PubMed:23512658, PubMed:20410308). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery (PubMed:10198427). May be involved in ATXN1 mutant-induced cell death (PubMed:12062018). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (PubMed:12062018). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (PubMed:21933836). Also acts as an innate immune sensor of infection by retroviruses, such as HIV, by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:26046437). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (PubMed:26046437)

The "PQBP1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PQBP1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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