PRICKLE3: A Potential Drug Target and Biomarker (G4007)

Target Name: PRICKLE3

NCBI ID: G4007

PRICKLE3

PRICKLE3: A Potential Drug Target and Biomarker

PRICKLE3, also known as Prickle planar cell polarity protein 3, is a protein that plays a crucial role in the maintenance of the integrity of the cell's plasma membrane. It is a member of the PIK family of proteins, which are involved in various cellular processes, including cell signaling, migration, and cytoskeletal organization. The PIK family has been implicated in a wide range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. PRICKLE3 has also been linked to various signaling pathways, including the PI3K/Akt signaling pathway, which is involved in cell survival, angiogenesis, and inflammation.

The Importance of PRICKLE3 in Cellular Signaling

PRICKLE3 is a key regulator of the PI3K/Akt signaling pathway, which is involved in the regulation of various cellular processes, including cell survival, angiogenesis, and inflammation. The PI3K/Akt pathway is a well-established signaling pathway that is involved in the regulation of cell proliferation, differentiation, migration, and survival. It is a complex signaling pathway that is involved in the regulation of many cellular processes, including the regulation of cell adhesion, the regulation of the cytoskeleton, and the regulation of cell survival.

PRICKLE3 is involved in the regulation of the PI3K/Akt pathway at the level of its expression and function. It is a key regulator of the PI3K/Akt signaling pathway, and its absence or dysfunction have been implicated in the development and progression of various diseases. For example, studies have shown that PRICKLE3 is involved in the regulation of cell survival and that its absence or dysfunction can lead to the development of cancer. Additionally, PRICKLE3 has been linked to the regulation of angiogenesis, the formation of new blood vessels, and the regulation of inflammation.

The Potential Role of PRICKLE3 as a Drug Target

The potential use of PRICKLE3 as a drug target is based on its involvement in the PI3K/Akt signaling pathway and its role in the regulation of cellular processes that are associated with the development and progression of various diseases. PRICKLE3 has been shown to be involved in the regulation of cell survival, angiogenesis, and inflammation, and its inhibition has been shown to have therapeutic effects in these diseases.

One of the potential therapeutic strategies for PRICKLE3 is to inhibit its activity, either by blocking its function through small molecule inhibitors or by blocking its expression. This would result in the inhibition of the PI3K/Akt signaling pathway, which would result in the inhibition of cellular processes that are associated with the development and progression of various diseases.

Another potential strategy for PRICKLE3 is to use it as a biomarker to diagnose and monitor diseases associated with the PI3K/Akt signaling pathway. This can be done by using techniques such as mass spectrometry to identify changes in the expression levels of PRICKLE3 and its associated downstream targets in response to therapeutic interventions or disease progression.

Conclusion

PRICKLE3 is a protein that plays a crucial role in the maintenance of the integrity of the cell's plasma membrane and is involved in various cellular processes that are associated with the development and progression of various diseases. Its potential as a drug target is based on its involvement in the PI3K/Akt signaling pathway and its role in the regulation of cellular processes that are associated with the development and progression of these diseases. Additionally, PRICKLE3 can be used as a biomarker to diagnose and monitor diseases associated with the PI3K/Akt signaling pathway. Further research is needed to fully understand the role of PRICKLE3

Protein Name: Prickle Planar Cell Polarity Protein 3

Functions: Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (By similarity). PCP is maintained by two molecular modules, the global and the core modules, PRICKLE3 being part of the core module (By similarity). Distinct complexes of the core module segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (By similarity). Involved in the organization of the basal body (By similarity). Involved in cilia growth and positioning (By similarity). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (PubMed:32516135)

The "PRICKLE3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PRICKLE3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets