ANGPTL5: A Potential Drug Target and Biomarker (G253935)

Target Name: ANGPTL5

NCBI ID: G253935

ANGPTL5

ANGPTL5: A Potential Drug Target and Biomarker

Angiopoietin-like protein 5 (ANGPTL5) is a protein that has been identified as a potential drug target and biomarker for various diseases, including heart failure, cancer, and neurodegenerative disorders.ANGPTL5 is a transmembrane protein that is expressed in various tissues, including the heart, kidneys, and brain. It is characterized by a unique extracellular domain that is composed of a hexameric repeat of the amino acid Asp-Glu-Asp (Glu-Asp) sequence.

The ANGPTL5 protein is involved in various physiological processes in the body, including inflammation, fibrosis, and autophagy. It has been shown to play a role in the regulation of cellular processes that are important for maintaining tissue homeostasis and repair.

One of the key functions of ANGPTL5 is its role in the regulation of angiogenesis, the process by which new blood vessels are formed. ANGPTL5 has been shown to promote the migration of progenitor cells from the bone marrow to the site of injury or disease, where it can differentiate into functional blood vessels. This function is critical for the development of new blood vessels, which is a critical component of tissue repair and regeneration.

In addition to its role in angiogenesis, ANGPTL5 has also been shown to play a role in the regulation of fibrosis, the thickening of connective tissue that occurs in response to injury or disease. Fibrosis is a complex process that can lead to the loss of tissue function and quality of life. ANGPTL5 has been shown to regulate the activity of fibroblasts, which are cells that produce collagen, a key component of connective tissue.

NGTL5 has also been shown to play a role in the regulation of cellular stress responses, which are critical for maintaining cellular homeostasis and responding to environmental stimuli. ANGPTL5 has also been shown to regulate the activity of stress response pathways, including the ADV signal transduction pathway (GAS pathway) and the nuclear factor kappa B (NF-kappa-B) pathway.

In addition to its role in cellular stress responses, ANGPTL5 has also been shown to play a role in the regulation of cellular adhesion. ANGPTL5 is involved in the formation of tight junctions, which are specialized structures that mediate cell-cell adhesion. This function is critical for the regulation of tissue structure and function, as well as the development of new tissues and organs.

NGTL5 has also been shown to play a role in the regulation of neurodegenerative disorders. As neurodegenerative disorders progress, the brain and nervous system are characterized by a progressive loss of neurons and the formation of neurofibrillary tangles. ANGPTL5 has also been shown to play a role in the regulation of neurofibrillary tangles, as well as the progression of neurodegenerative disorders.

In conclusion, ANGPTL5 is a protein that has been identified as a potential drug target and biomarker for various diseases. Its unique extracellular domain and various functions in cellular processes, including angiogenesis, fibrosis, and stress responses, make it an attractive target for drug development . Further research is needed to fully understand the role of ANGPTL5 in disease and to develop effective therapies.

Protein Name: Angiopoietin Like 5

The "ANGPTL5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ANGPTL5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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