ANK2: A Potential Drug Target and Biomarker (G287)

Target Name: ANK2

NCBI ID: G287

ANK2

ANK2: A Potential Drug Target and Biomarker

Ankyrin 2 (ANK2) is a non-coding RNA molecule that has been identified as a potential drug target and biomarker for several diseases. ANK2 is a key regulator of the cell cycle and is involved in the development and maintenance of normal cell structure and function. ANK2 has been shown to be aberrantly expressed in several types of cancer, including breast, ovarian, and colorectal cancer. Additionally, ANK2 has been associated with the development of neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases.

The ANK2 gene was first identified in the genomic database using computational methods. It is located on chromosome 6 and has been shown to encode a protein that is involved in the regulation of the cell cycle. Studies have shown that ANK2 is highly expressed in various tissues and that it is involved in the development and maintenance of normal cell structure and function.

One of the key functions of ANK2 is its role in the regulation of the cell cycle. The cell cycle is the process by which a cell grows, replicates its DNA, and divides. ANK2 is involved in the regulation of the steps of the cell cycle, including the G1 phase, the S phase, and the G2 phase. During the G1 phase, ANK2 promotes the growth of the cell and the acquisition of new genetic material. During the S phase, ANK2 ensures that the cell has enough DNA to replicate and that the replicated DNA is properly organized. During the G2 phase, ANK2 promotes the preparation of the cell for cell division.

In addition to its role in the cell cycle, ANK2 has also been shown to be involved in the regulation of cell adhesion. ANK2 has been shown to be involved in the formation of tight junctions, which are the junctions that separate cells from the surrounding tissue. tight junctions are important for maintaining the integrity of the cell membrane and for controlling the movement of substances into and out of the cell.

The ANK2 gene has also been associated with the development of neurodegenerative diseases. Alzheimer's and Parkinson's diseases are two of the most common forms of neurodegenerative diseases. These diseases are characterized by the progressive loss of brain cells and the development of characteristic symptoms. Studies have shown that ANK2 is aberrantly expressed in the brains of individuals with Alzheimer's and Parkinson's diseases. Additionally, ANK2 has been shown to be involved in the development of other neurodegenerative diseases, such as ALS and Huntington's diseases.

In conclusion, ANK2 is a non-coding RNA molecule that has been shown to be involved in the regulation of the cell cycle and cell adhesion. It has also been associated with the development of neurodegenerative diseases. As a potential drug target, ANK2 may be a valuable target for the development of new therapies for these diseases. Further research is needed to fully understand the role of ANK2 in the development and progression of neurodegenerative diseases.

Protein Name: Ankyrin 2

Functions: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity)

The "ANK2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ANK2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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