ANKRD27: A Potential Drug Target and Biomarker (G84079)

Target Name: ANKRD27

NCBI ID: G84079

ANKRD27

ANKRD27: A Potential Drug Target and Biomarker

Introduction

Ankyrin domain-containing proteins (ACKs) are a family of transmembrane proteins that play a crucial role in various cellular processes. One of the most well-known members of this family is ANKRD27, a protein that has been identified as a drug potential target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. In this article, we will explore the ANKRD27 protein, its function, potential drug targets, and its potential as a biomarker.

Function of ANKRD27

The ANKRD27 protein is a 27 kDa transmembrane protein that contains an N-terminal ankyrin domain, a central 尾-sheet, and a C-terminal T-loop. It has been shown to play a role in various cellular processes, including cell signaling, protein-protein interactions, and intracellular signaling pathways.

One of the most significant functions of ANKRD27 is its role in intracellular signaling pathways. The ankyrin domain of ANKRD27 is involved in the regulation of protein-protein interactions and in the formation of protein-protein domains. This domain has been shown to interact with various protein partners, including tyrosine kinases, serpins, and G-protein-coupled receptors. These interactions play a crucial role in regulating cellular signaling pathways and are involved in the development of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Potential Drug Targets

The potential drug targets for ANKRD27 are numerous and varied. One of the most promising targets is its role in cancer, where ANKRD27 has been shown to be involved in the development and progression of various types of cancer, including breast, ovarian, and prostate cancer . ANKRD27 has also been shown to play a role in the regulation of cell cycle progression and has been shown to interact with various oncogenic factors, including tyrosine kinases and hedgehog signaling pathway components.

Another potential drug target for ANKRD27 is its role in neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. ANKRD27 has been shown to play a role in the regulation of neurotransmitter release and has been shown to interact with various neurotransmitter receptors, including dopamine, serotonin , and GABA. These interactions play a crucial role in the development and progression of neurodegenerative diseases.

In addition to its potential drug targets, ANKRD27 has also been shown to be a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The expression of ANKRD27 has been shown to be associated with the development and progression of various diseases. , including cancer and neurodegenerative diseases.

Potential as a Biomarker

The potential use of ANKRD27 as a biomarker for various diseases is a promising area of 鈥嬧?媟esearch. The expression of ANKRD27 has been shown to be associated with the development and progression of various diseases, including cancer and neurodegenerative diseases. This suggests that ANKRD27 may be a useful biomarker for these diseases.

One of the key advantages of ANKRD27 as a biomarker is its stability and the ease with which it can be measured. ANKRD27 is a protein that is expressed in most tissues and cells, making it a potentially useful biomarker for a wide range of diseases. Additionally , the expression of ANKRD27 can be measured using various techniques, including Western blotting, immunofluorescence, and mass spectrometry. This makes it

Protein Name: Ankyrin Repeat Domain 27

Functions: May be a guanine exchange factor (GEF) for Rab21, Rab32 and Rab38 and regulate endosome dynamics (PubMed:16525121, PubMed:18477474). May regulate the participation of VAMP7 in membrane fusion events; in vitro inhibits VAMP7-mediated SNARE complex formation by trapping VAMP7 in a closed, fusogenically inactive conformation (PubMed:23104059). Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with Rab32, Rab38 and VAMP7 (By similarity). Involved in the regulation of neurite growth; the function seems to require its GEF activity, probably towards Rab21, and VAMP7 but not Rab32/38 (By similarity). Proposed to be involved in Golgi sorting of VAMP7 and transport of VAMP7 vesicles to the cell surface; the function seems to implicate kinesin heavy chain isoform 5 proteins, GOLGA4, RAB21 and MACF1 (PubMed:22705394). Required for the colocalization of VAMP7 and Rab21, probably on TGN sites (PubMed:19745841). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with VPS29 (PubMed:24856514). Regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity)

The "ANKRD27 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ANKRD27 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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