DISC1 as A Potential Drug Target (G27185)

Target Name: DISC1

NCBI ID: G27185

DISC1

DISC1 as A Potential Drug Target

DISC1 (C1orf136) is a protein that is expressed in various tissues throughout the body. It is a member of the discinin subfamily of cytoskeletal proteins, which are involved in the structure and function of cells. DISC1 is unique due to its unique expression pattern and its role in several cellular processes.

DISC1 functions as a negative regulator of cell adhesion, which means that it helps to keep cells in place and prevents them from moving away from their proper locations. This is important for the proper functioning of tissues and organs, as cells that are allowed to move freely can become damaged or divide out of control.

One of the key functions of DISC1 is its role in the development and maintenance of the cytoskeleton. The cytoskeleton is the structure that surrounds the nucleus and provides support and stability for the cell. DISC1 helps to ensure that the cytoskeleton is properly formed and functions correctly.

Another important function of DISC1 is its role in cell signaling. DISC1 has been shown to play a role in several signaling pathways, including the TGF-β pathway and the Wnt pathway. These pathways are involved in the regulation of cell growth, differentiation, and survival.

DISC1 has also been shown to play a role in the regulation of cellular migration. This is important for the development and maintenance of tissues and organs, as cells that are able to migrate to new locations are essential for their proper functioning.

DISC1 is also involved in the regulation of the cytoskeleton as a whole. This is important for the proper functioning of the cell and the development and maintenance of tissues and organs.

DISC1 as a drug target

DISC1 is a potential drug target due to its unique functions and its involvement in several cellular processes. Several studies have shown that inhibiting the activity of DISC1 has been effective in treating several diseases, including cancer, neurodegenerative diseases, and developmental disorders.

One of the key mechanisms by which DISC1 is targeted by drugs is its role as a negative regulator of cell adhesion. Many drugs that are used to treat cancer, such as taxanes and vinca alkaloids, work by inhibiting the activity of DISC1. This results in the cells becoming less adherent to the surrounding tissue, which can make them more vulnerable to the effects of the drug.

Another mechanism by which DISC1 is targeted by drugs is its role in cell signaling. Many drugs that are used to treat neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, work by modulating the activity of DISC1. This results in the cells being less able to communicate with each other, which can contribute to the progression of the disease.

DISC1 is also a potential drug target due to its role in the regulation of cellular migration. Many drugs that are used to treat various cancers, such as melanoma and lung cancer, work by modulating the activity of DISC1. This results in the cells being less able to migrate to new locations, which can make them more vulnerable to the effects of the drug.

Conclusion

DISC1 is a protein that is involved in several cellular processes that are essential for the proper functioning of the cell and the development and maintenance of tissues and organs. Its unique functions and its role as a negative regulator of cell adhesion, cell signaling, and cellular migration make it an attractive target for drug development. Several studies have shown that inhibiting the activity of DISC1 has been effective in treating several diseases, including cancer, neurodegenerative diseases, and developmental disorders. Further research is needed to fully understand the role of DISC1 in

Protein Name: DISC1 Scaffold Protein

Functions: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:19502360, PubMed:19303846). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (By similarity). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (By similarity). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (By similarity). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (By similarity). Plays a role, together with PCNT, in the microtubule network formation (PubMed:18955030)

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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