Recombinant porin REC114: a promising drug target and potential biomarker

Target Name: REC114

NCBI ID: G283677

REC114

Recombinant porin REC114: a promising drug target and potential biomarker

Summary

Recombinant porin REC114 (isoform 1) is a protein with unique functions that plays a key role in a variety of physiological processes. In recent years, researchers have continued to conduct in-depth research on REC114 and discovered its potential in the field of drug targets and biomarkers. This article aims to provide a comprehensive review of the research progress on the structure, function, drug targets and biomarkers of REC114, with a view to providing useful inspiration for future research on REC114.

1. Structure and function

REC114 is a eukaryotic porin that belongs to a non-conserved family. Its unique pore structure gives it a wide range of protein-binding capabilities. REC114 consists of 114 amino acids and its molecular weight is 18.5 kDa. REC114 has two main isoforms: REC114-伪 and REC114-尾, which differ in the type of the last amino acid. REC114-伪 has a high expression level in cells and is mainly involved in intracellular signal transduction, metabolic regulation and other processes; while REC114-尾 is mainly involved in extracellular signal transduction, cell adhesion and other physiological processes.

The pore structure of REC114 is the basis for its unique functionality. The pore structure of REC114 is divided into two main parts: the pore domain and the background area. The pore domain is where REC114 binds to the protein and is composed of 45% alpha helices and 30% beta sheets. The background area is the prosthetic group where REC114 binds to the protein, which is mainly composed of 20% 伪-helix and 35% 尾-sheet. This separated pore structure enables REC114 to have high binding specificity and can specifically bind to various proteins.

2. Drug Targets

The potential of REC114 in drug target research has attracted widespread attention. In recent years, researchers have discovered through high-throughput screening and domain analysis methods that REC114 has a variety of drug target properties, such as affinity for interacting with drug molecules and stability in vivo. These findings lay the foundation for the development of drugs targeting REC114.

1. Drug target characteristics

(1) Affinity: The affinity of a drug to REC114 is an important indicator of drug selectivity. The separated pore structure of REC114 gives it high binding specificity and can specifically bind to various proteins. This makes REC114 have a significantly higher affinity for drug molecules than other proteins.

(2) Stability: The stability of REC114 in vivo is of great significance for the development of long-term therapeutic drugs. The stability of drugs in vivo is closely related to their pore structure characteristics. The pore structure separation of REC114 makes it highly stable and can be stably expressed in vivo for a long time.

2. Drug target prediction

Through methods such as high-throughput screening and domain analysis, researchers speculated on the drug targets that REC114 may be involved in. These drug targets include: ion channels, protein kinases, phosphorylase, etc. By intervening on these targets, the toxic and side effects of drugs can be reduced and the efficacy of drugs can be improved.

3. Biomarkers

REC114 has also received widespread attention for its potential in biomarker research. Biomarkers refer to molecules or cell groups that can reflect a specific physiological process or state in an organism. Through the study of REC114 in biomarkers, we can better understand the function and mechanism of REC114 in organisms.

1. Biomarker discovery

By detecting REC114 gene expression and expression products, researchers discovered a variety of biomarkers. These biomarkers can be used to evaluate the expression level and stability of REC114 in vivo. At the same time, through the study of REC114 biomarkers, the mechanism of action of REC114 in the organism can be revealed, providing a theoretical basis for drug design and clinical application.

2. Biomarker Analysis

Analysis of REC114 biomarkers can reveal the role of REC114 in vivo

Protein Name: REC114 Meiotic Recombination Protein

Functions: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis

The "REC114 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about REC114 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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