LINC00469: A Long Intergenic Non-Protein-Coding RNA as a Drug Target and Biomarker

Target Name: LINC00469

NCBI ID: G283982

LINC00469

Other Name(s): long intergenic non-protein coding RNA 469 | Long intergenic non-protein coding RNA 469 | C17orf54

LINC00469: A Long Intergenic Non-Protein-Coding RNA as a Drug Target and Biomarker

LINC00469 is a long intergenic non-protein-coding RNA (lncRNA) molecule, which has been identified using RNA-seq technology. It is characterized by its unique 5' and 3' ends, which give it a length of approximately 290 nucleotides. LINC00469 is expressed in various tissues and cell types, including brain, heart, and muscle. It has been shown to be involved in various cellular processes, including cell adhesion, migration, and transcriptional regulation.

Drug Target Potential

LINC00469 has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. One of the key reasons for its potential as a drug target is its unique 5' and 3' ends, which give it a unique shape that can interact with various signaling molecules. Additionally, its expression has been shown to be regulated by various signaling pathways, including TGF-β and NF-kappa-B signaling pathways.

Furthermore, LINC00469 has been shown to play a role in various cellular processes that are related to disease, such as cancer, neurodegenerative diseases, and cardiovascular diseases. For example, LINC00469 has been shown to be involved in the regulation of cell adhesion, which is a critical process for the development and progression of cancer. Additionally, LINC00469 has been shown to be involved in the regulation of neural stem/progenitor cell (NSC) proliferation and differentiation, which is critical for the development and treatment of neurodegenerative diseases.

Biomarker Potential

LINC00469 has also been identified as a potential biomarker for various diseases, including cancer, neurodegenerative diseases, and cardiovascular diseases. For example, LINC00469 has been shown to be downregulated in various types of cancer, including breast, ovarian, and prostate cancer. Additionally, LINC00469 has been shown to be involved in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Animal Models

To study the potential drug target and biomarker properties of LINC00469, several animal models have been created. One of the most promising models is the GFP-LCN model, which uses the green fluorescent protein (GFP) to label LINC00469 RNA and visualize its expression in live animals. This model has been used to study the effects of various drugs on LINC00469 expression and its role in cellular processes.

Another promising model is the RNAi-LCN model, which uses RNA interference (RNAi) to knockdown LINC00469 expression in animals. This model has been used to study the effects of RNAi on LINC00469 expression and its role in cellular processes.

In conclusion, LINC00469 is a long intergenic non-protein-coding RNA that has been identified as a potential drug target due to its unique structure and its involvement in various cellular processes. Its expression has been shown to be regulated by various signaling pathways, including TGF-β and NF-kappa-B signaling pathways, and it has been shown to play a role in various cellular processes, including cell adhesion, migration, and transcriptional regulation. Additionally, LINC00469 has been shown to be involved in the regulation of neural stem/progenitor cell (NSC) proliferation and differentiation, which is critical for the development and treatment of neurodegenerative diseases. As a potential biomarker, LINC00469 has been shown to be downregulated in various types of cancer and has been shown to be involved in the regulation of neurodegenerative diseases.

Overall, LINC00469 is a promising candidate for further study as a drug target and biomarker. Further studies are needed to confirm its potential and determine its exact role in various cellular processes and diseases.

Protein Name: Long Intergenic Non-protein Coding RNA 469

The "LINC00469 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about LINC00469 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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